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Imidazole

Name: Imidazole
Brand: TargetMol
SKU: T5202
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5202Cas No. 288-32-4

Alias Glyoxaline, 1,3-diazole, 1,3-Diaza-2,4-cyclopentadiene

Imidazole is a planar 5-membered ring and a highly polar compound. It has been used extensively as a corrosion inhibitor. Imidazole is incorporated into many important biological molecules.

Imidazole

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Purity: 98.94%

Catalog No. T5202Alias Glyoxaline, 1,3-diazole, 1,3-Diaza-2,4-cyclopentadieneCas No. 288-32-4

Imidazole is a planar 5-membered ring and a highly polar compound. It has been used extensively as a corrosion inhibitor. Imidazole is incorporated into many important biological molecules.

Pack Size	Price	USA Warehouse	Global Warehouse
25 g	$35	-	In Stock
50 g	$50	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.94%

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Imidazole AI Summary

Imidazole displays multiple bioactivities across various biological assays. It has a dissociation constant (pKa) value reported to be around 7.0, which suggests its ionization behavior and potential interactions in biological systems. The compound enhances styrene oxide hydrolase activity with specific parameters showing maximum enhancement at a concentration of 1e-1M and an E100 of 0.0088 M. It also exhibits inhibitory activities against thromboxane A2 synthetase (IC50 of 670,000 nM), porcine aorta prostacyclin PGI-2 synthase (IC50 of 4,000,000 nM), and calmodulin-dependent bovine neuronal NOS (IC50 of 200,000 nM). In terms of antiplasmodial activity, the compound inhibits Plasmodium falciparum 3D7 with an IC50 of 368,000 nM. Additionally, it shows no significant inhibition of ram seminal vesicle Cyclooxygenase (IC50 > 10,000,000 nM) and no antifungal activity against Candida albicans strains. Furthermore, compound 13355 inhibits epoxide hydrolase (Log 1/E100 value of 2.05) and is a CYP3A4 inhibitor with an IC50 greater than 10,000 nM. It also shows cytotoxicity against various human cell lines and interacts with human CYP1B1 (Ks = 1255.0 uM) and FKBP51 protein (Kd = 4,400,000 nM), as well as inhibiting recombinant human QC with an IC50 of 352,000 nM. The partition coefficient (logP) of -0.42 underscores its solubility characteristics. These bioactivities, along with its physicochemical properties, make Imidazole a multifaceted molecule with diverse implications in biochemical research..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Imidazole is a planar 5-membered ring and a highly polar compound. It has been used extensively as a corrosion inhibitor. Imidazole is incorporated into many important biological molecules.
Synonyms	Glyoxaline, 1,3-diazole, 1,3-Diaza-2,4-cyclopentadiene

Chemical Properties

Molecular Weight	68.08
Formula	C₃H₄N₂
Cas No.	288-32-4
Smiles	N1C=CN=C1
Relative Density.	1.01 g/cm3 at 20℃

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 240 mg/mL (3525.26 mM), Sonication is recommended.

H2O: 95 mg/mL (1395.42 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (48.47 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	14.6886 mL	73.4430 mL	146.8860 mL	734.4301 mL
5 mM	2.9377 mL	14.6886 mL	29.3772 mL	146.8860 mL
10 mM	1.4689 mL	7.3443 mL	14.6886 mL	73.4430 mL
20 mM	0.7344 mL	3.6722 mL	7.3443 mL	36.7215 mL
50 mM	0.2938 mL	1.4689 mL	2.9377 mL	14.6886 mL
100 mM	0.1469 mL	0.7344 mL	1.4689 mL	7.3443 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc