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ML-298
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Catalog No. T8966Cas No. 1426916-02-0
Alias ML298, CID53393915
ML-298 (CID53393915) is a potent, specific inhibitor of Phospholipase D2 (PLD2, IC50 of 355 nM).
ML-298
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Purity: 99.35%
Catalog No. T8966Alias ML298, CID53393915Cas No. 1426916-02-0
ML-298 (CID53393915) is a potent, specific inhibitor of Phospholipase D2 (PLD2, IC50 of 355 nM).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $34 | In Stock | In Stock | |
| 5 mg | $80 | In Stock | In Stock | |
| 10 mg | $128 | In Stock | In Stock | |
| 25 mg | $219 | In Stock | In Stock | |
| 50 mg | $326 | In Stock | In Stock | |
| 100 mg | $486 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $97 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.35%
Appearance:Solid
Color:White
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Product Introduction
ML-298 AI Summary
ML-298 demonstrates a range of bioactivities including moderate to high exposure in mouse lung and plasma, along with low brain penetration as indicated by AUC ratios. It has a low fraction unbound in both rat and human plasma after 4 hours via equilibrium dialysis. The compound exhibits inhibitory effects on CYP2D6 and CYP3A4 enzymes, but not on CYP2C9 or CYP1A2, and does not significantly inhibit human ERG, MOP receptor, and KOP receptor at 10 µM. Clearance rates are relatively high in both human and rat liver microsomes.
In terms of target specificity, ML-298 inhibits GFP-tagged PLD2 in human HEK293 cells with an IC50 of 355.0 nM but is not active against PLD1 in human Calu-1 cells, displaying a selectivity ratio (PLD1/PLD2) greater than 53.0. Moreover, it demonstrates antiviral activity by inhibiting SARS-CoV-2-induced cytotoxicity in both Caco-2 and VERO-6 cells, though with low inhibition percentages of -0.63% and 14.12% respectively at 10 µM after 48 hours. Additionally, the compound shows minimal inhibition of SARS-CoV-2 3CL-Pro protease (0.17% at 20 µM) and slight inhibitory bioactivity against human HDAC6 in enzymatic assays with inhibition percentages of 7.38% and 8.27% respectively..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ML-298 (CID53393915) is a potent, specific inhibitor of Phospholipase D2 (PLD2, IC50 of 355 nM). |
| Targets&IC50 | PLD2:355 nM |
| Synonyms | ML298, CID53393915 |
| Molecular Weight | 432.44 |
| Formula | C22H23F3N4O2 |
| Cas No. | 1426916-02-0 |
| Smiles | Fc1cccc(c1)N1CNC(=O)C11CCN(CCNC(=O)c2ccc(F)c(F)c2)CC1 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 9 mg/mL (20.81 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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