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TPC2-A1-P

🥰Excellent
Catalog No. T36806Cas No. 2804595-86-4

TPC2-A1-P is a membrane-permeable two-pore channel 2 (TPC2) agonist that differentially activates two-pore channel 2 (TPC2) and mimics the activation of TPC2 with NAADP and PIP(2). TPC2-A1-P can be used to study neurodegenerative lysosomal storage diseases.

TPC2-A1-P

TPC2-A1-P

🥰Excellent
Purity: 98.49%
Catalog No. T36806Cas No. 2804595-86-4
TPC2-A1-P is a membrane-permeable two-pore channel 2 (TPC2) agonist that differentially activates two-pore channel 2 (TPC2) and mimics the activation of TPC2 with NAADP and PIP(2). TPC2-A1-P can be used to study neurodegenerative lysosomal storage diseases.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$98In StockIn Stock
5 mg$249In StockIn Stock
10 mg$415In StockIn Stock
25 mg$789-In Stock
50 mg$1,280-In Stock
100 mg$1,950-In Stock
1 mL x 10 mM (in DMSO)$252-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:98.49%
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Product Introduction

Bioactivity
Description
TPC2-A1-P is a membrane-permeable two-pore channel 2 (TPC2) agonist that differentially activates two-pore channel 2 (TPC2) and mimics the activation of TPC2 with NAADP and PIP(2). TPC2-A1-P can be used to study neurodegenerative lysosomal storage diseases.
Targets&IC50
TPC2:50 μM (EC50)
In vitro
METHODS: Cell lines stably expressing TPC2L11A/L12A were screened with natural and synthetic small molecule libraries using a FLIPR-based Ca2+ assay, and after screening, the structure and activity of TPC2-A1-P (0.1-100 μM) and TPC2-A1-N (T36805) were confirmed by independent chemical synthesis and subsequent retesting.
RESULTS: Plateau-responsive full-concentration effect relationships indicated EC50 values of 10.5 and 7.8 μM for TPC2-A1-P and TPC2-A1-N, respectively, and confirmed their Ca2+ solubility in intact cells. [1]
Chemical Properties
Molecular Weight460.29
FormulaC20H21BrF3NO3
Cas No.2804595-86-4
SmilesO=C(O)C=1C=C(C=2C=C(Br)C=CC2OC(F)(F)F)N(C1C)CC3CCCCC3
Storage & Solubility Information
Storagekeep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (86.9 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 2 mg/mL (4.35 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1725 mL10.8627 mL21.7254 mL108.6272 mL
5 mM0.4345 mL2.1725 mL4.3451 mL21.7254 mL
10 mM0.2173 mL1.0863 mL2.1725 mL10.8627 mL
20 mM0.1086 mL0.5431 mL1.0863 mL5.4314 mL
50 mM0.0435 mL0.2173 mL0.4345 mL2.1725 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Keywords

TPC2-A1-PTPC-2-A1-PTPC2A1PTPC2 A1 PTPC2CalciumChannelCalcium Channel
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