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TPC2-A1-P

Name: TPC2-A1-P
Brand: TargetMol
SKU: T36806
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36806Cas No. 2804595-86-4

TPC2-A1-P is a membrane-permeable two-pore channel 2 (TPC2) agonist that differentially activates two-pore channel 2 (TPC2) and mimics the activation of TPC2 with NAADP and PIP(2). TPC2-A1-P can be used to study neurodegenerative lysosomal storage diseases.

TPC2-A1-P

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Purity: 98.49%

Catalog No. T36806Cas No. 2804595-86-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$98	In Stock	In Stock
5 mg	$249	In Stock	In Stock
10 mg	$415	In Stock	In Stock
25 mg	$789	-	In Stock
50 mg	$1,280	-	In Stock
100 mg	$1,950	-	In Stock
1 mL x 10 mM (in DMSO)	$252	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.49%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	TPC2-A1-P is a membrane-permeable two-pore channel 2 (TPC2) agonist that differentially activates two-pore channel 2 (TPC2) and mimics the activation of TPC2 with NAADP and PIP(2). TPC2-A1-P can be used to study neurodegenerative lysosomal storage diseases.
Targets&IC50	TPC2:50 μM (EC50)
In vitro	METHODS: Cell lines stably expressing TPC2L11A/L12A were screened with natural and synthetic small molecule libraries using a FLIPR-based Ca2+ assay, and after screening, the structure and activity of TPC2-A1-P (0.1-100 μM) and TPC2-A1-N (T36805) were confirmed by independent chemical synthesis and subsequent retesting. RESULTS: Plateau-responsive full-concentration effect relationships indicated EC50 values of 10.5 and 7.8 μM for TPC2-A1-P and TPC2-A1-N, respectively, and confirmed their Ca2+ solubility in intact cells. [1]

Chemical Properties

Molecular Weight	460.29
Formula	C₂₀H₂₁BrF₃NO₃
Cas No.	2804595-86-4
Smiles	O=C(O)C=1C=C(C=2C=C(Br)C=CC2OC(F)(F)F)N(C1C)CC3CCCCC3

Storage & Solubility Information

Storage

keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (86.9 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (4.35 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1725 mL	10.8627 mL	21.7254 mL	108.6272 mL
5 mM	0.4345 mL	2.1725 mL	4.3451 mL	21.7254 mL
10 mM	0.2173 mL	1.0863 mL	2.1725 mL	10.8627 mL
20 mM	0.1086 mL	0.5431 mL	1.0863 mL	5.4314 mL
50 mM	0.0435 mL	0.2173 mL	0.4345 mL	2.1725 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc