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Anti-KIR2DL1 Antibody-APC (4W251)
🥰Excellent
Catalog No. TMAY-02503A
Anti-KIR2DL1 Antibody-APC (4W251) is a APC-conjugated Rabbit antibody targeting KIR2DL1. Anti-KIR2DL1 Antibody-APC (4W251) can be used in FCM.
Anti-KIR2DL1 Antibody-APC (4W251)
Anti-KIR2DL1 Antibody-APC (4W251)
🥰Excellent
Catalog No. TMAY-02503A
Anti-KIR2DL1 Antibody-APC (4W251) is a APC-conjugated Rabbit antibody targeting KIR2DL1. Anti-KIR2DL1 Antibody-APC (4W251) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-KIR2DL1 Antibody-APC (4W251) is a APC-conjugated Rabbit antibody targeting KIR2DL1. Anti-KIR2DL1 Antibody-APC (4W251) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 4W251 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of human KIR2DL1(CD158a) expression on human whole blood lymphocytes. Human whole blood lymphocytes were stained with APC-conjugated anti-Human KIR2DL1(CD158a). The histogram were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes. |
| Application | FCM |
| Recommended Dose | 10 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human KIR2DL1 / CD158a (rh KIR2DL1 / CD158a; TMPY-02629; NP_055033.2; Met1-His245) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | Killer cell immunoglobulin-like receptor 2DL1 or KIR2DL1 is an inhibitory Natural Killer cell immunoglobulin-like receptor with two extracellular immunoglobulin domains. KIR2DL1 is a member of the Killer cell immunoglobulin-like receptor family whose members are classified by the number of the extracellular immunoglobulin domains and the length of the cytoplasm domain. KIR2DL1 is a transmembrane glycoprotein expressed by natural killer cells and subsets of T cells. KIR2DL1 down-regulates the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. It has been reported that the KIR2DL1 is bound to its class I MHC ligand, HLA-Cw4. The KIR2DL1-HLA-Cw4 interface exhibits charge and shape complementarity. Specificity is mediated by a pocket in KIR2DL1 that hosts the Lys80 residue of HLA-Cw4. Many residues conserved in HLA-C and KIR2DL receptors make different interactions in KIR2DL1-HLA-Cw4 and a previously reported KIR2DL2-HLA-Cw3 complex. A dimeric aggregate of KIR-HLA-C complexes was observed in one KIR2DL1-HLA-Cw4 crystal. |
| Conjucates | APC |
| Others Formats | Unconjugated/PerCP/FITC/PE |
| Antibody Types Available | 5 |
| Immunogen | Recombinant Human KIR2DL1 / CD158a protein (TMPY-02629) |
| Antigen Species | Human |
| Biology Area | ITIM/ITAM Immunoreceptors and Related Molecules |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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