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Hexadimethrine bromide (Synonyms: Polybrene, 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide)

Name: Hexadimethrine bromide
Brand: TargetMol
SKU: T13720
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T13720 Copy Product Info

Purity: 99.35%

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Hexadimethrine bromide (1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide) is a synthetic polymer which agglutinates red blood cells, and used as a heparin antagonist.

Hexadimethrine bromide

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Catalog No. T13720

Synonyms Polybrene, 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide

Hexadimethrine bromide (1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide) is a synthetic polymer which agglutinates red blood cells, and used as a heparin antagonist.

Cas No. 28728-55-4

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Pack Size	Price	USA Stock	Global Stock
50 mg	$41	-	In Stock
100 mg	$66	-	In Stock
200 mg	$94	-	In Stock
500 mg	$158	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.35%

Color:White

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COA LCMS

Product Introduction

Bioactivity

Description	Hexadimethrine bromide (1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide) is a synthetic polymer which agglutinates red blood cells, and used as a heparin antagonist.
In vitro	Hexadimethrine bromide impedes the proliferation of human mesenchymal stem cells during lentiviral transduction and is deemed non-toxic at low concentrations. Yet, at levels exceeding 10 µg/mL, it adversely impacts the proliferation of certain cell types. Moreover, cells treated with Hexadimethrine bromide and then trypsinized appear significantly enlarged under microscopic examination.
Synonyms	Polybrene, 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide

Chemical Properties

Molecular Weight	404.275
Formula	(C₁₃H₃₀N₂)n.Br₂
Cas No.	28728-55-4
Smiles	[Br-].[Br-].CCCCCCC[N+](C)(C)CCC[N+](C)(C)C
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture,store under nitrogen | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.50 mg/mL (11.13 mM), Sonication and heating are recommended.

H2O: 125.00 mg/mL (309.20 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.4736 mL	12.3678 mL	24.7356 mL	123.6782 mL
5 mM	0.4947 mL	2.4736 mL	4.9471 mL	24.7356 mL
10 mM	0.2474 mL	1.2368 mL	2.4736 mL	12.3678 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.1237 mL	0.6184 mL	1.2368 mL	6.1839 mL
50 mM	0.0495 mL	0.2474 mL	0.4947 mL	2.4736 mL
100 mM	0.0247 mL	0.1237 mL	0.2474 mL	1.2368 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

InhibitorinhibitHexadimethrine bromideHexadimethrineheparin