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Anti-IL-1RA Antibody (9M986)
😃Good
Catalog No. TMAY-00054
Alias interleukin 1 receptor antagonist
Anti-IL-1RA Antibody (9M986) is a Rabbit antibody targeting IL-1RA. Anti-IL-1RA Antibody (9M986) can be used in IHC-P.
Anti-IL-1RA Antibody (9M986)
Anti-IL-1RA Antibody (9M986)
😃Good
Catalog No. TMAY-00054Alias interleukin 1 receptor antagonist
Anti-IL-1RA Antibody (9M986) is a Rabbit antibody targeting IL-1RA. Anti-IL-1RA Antibody (9M986) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-IL-1RA Antibody (9M986) is a Rabbit antibody targeting IL-1RA. Anti-IL-1RA Antibody (9M986) can be used in IHC-P. |
| Alias | interleukin 1 receptor antagonist |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 9M986 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human IL1RA in human skin with rabbit monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human IL1RA in human kidney with rabbit monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:50-1:200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with a synthetic peptide corresponding to the center region of the human IL1Ra / IL1RN. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Interleukin-1 receptor antagonist (IL-1RA) also known as IL1RN is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A), and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. A polymorphism of this protein-encoding gene is reported to be associated with an increased risk of osteoporotic fractures and gastric cancer. IL-1RA/IL1RN may inhibit the activity of IL-1 by binding to its receptor and it has no IL-1 like activity. Genetic variation in IL-1RA/IL1RN is associated with susceptibility to microvascular complications of diabetes type 4 (MVCD4). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Defects in IL-1RA/IL1RN are the cause of interleukin 1 receptor antagonist deficiency (DIRA) which is also known as deficiency of interleukin 1 receptor antagonist. Autoinflammatory diseases manifest inflammation without evidence of infection, high-titer autoantibodies, or autoreactive T-cells. DIRA is a rare, autosomal recessive, genetic autoinflammatory disease that results in sterile multifocal osteomyelitis, and pustulosis from birth. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide corresponding to the center region of the human IL1Ra / IL1RN. |
| Antigen Species | Human |
| Biology Area | Neuroinflammation |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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