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GITR Ligand/TNFSF18 Protein, Cynomolgus, Recombinant (His)
(Synonyms: Tumor necrosis factor ligand superfamily member 18, TNFSF18, TL6, Glucocorticoid-induced TNF-related ligand, GITRL, AITRL, Activation-inducible TNF-related ligand) Copy Product InfoSynonyms: Tumor necrosis factor ligand superfamily member 18, TNFSF18, TL6, Glucocorticoid-induced TNF-related ligand, GITRL, AITRL, Activation-inducible TNF-related ligand
Catalog No. TMPJ-00432 Copy Product Info
TNFSF18 is a single-pass type II membrane protein. It is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 cytokine binds to TNFRSF18/AITR/GITR. It regulates T-cell responses, and functions as costimulator and lower the threshold for T-cell activation and T-cell proliferation. It is Important for interactions between activated T-lymphocytes and endothelial cells and Promotes leukocyte adhesion to endothelial cells. TNFSF18 mediates activation of NF-kappa-B. As Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. It also regulates migration of monocytes from the splenic reservoir to sites of inflammation.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $55 | 35 days | 35 days | |
| 10 μg | $86 | 35 days | 35 days | |
| 20 μg | $137 | 35 days | 35 days | |
| 50 μg | $262 | 35 days | 35 days | |
| 100 μg | $488 | 35 days | 35 days | |
| 200 μg | $923 | 35 days | 35 days | |
| 500 μg | $2,150 | 35 days | 35 days | |
| 1 mg | $3,220 | 35 days | 35 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | TNFSF18 is a single-pass type II membrane protein. It is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 cytokine binds to TNFRSF18/AITR/GITR. It regulates T-cell responses, and functions as costimulator and lower the threshold for T-cell activation and T-cell proliferation. It is Important for interactions between activated T-lymphocytes and endothelial cells and Promotes leukocyte adhesion to endothelial cells. TNFSF18 mediates activation of NF-kappa-B. As Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. It also regulates migration of monocytes from the splenic reservoir to sites of inflammation. |
| Species | Cynomolgus |
| Expression System | HEK293 Cells |
| Tag | C-6xHis |
| Accession Number | A0A2K5UCD9 |
| Amino Acid | Glu74-Ser199 |
| Construction | Glu74-Ser199 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | Tumor necrosis factor ligand superfamily member 18, TNFSF18, TL6, Glucocorticoid-induced TNF-related ligand, GITRL, AITRL, Activation-inducible TNF-related ligand |
| Research Background |
| Molecular Weight | 15-20 KDa (reducing condition) |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: GITR Ligand/TNFSF18 Protein, Cynomolgus, Recombinant (His) chemical structure | GITR Ligand/TNFSF18 Protein, Cynomolgus, Recombinant (His) molecular weight
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