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Ethopropazine Hydrochloride
🥰Excellent
Catalog No. T21393Cas No. 1094-08-2
Alias Profenamine HCl, Parsidol hydrochloride, Lysivane hydrochloride, Isothazine hydrochloride
Ethopropazine Hydrochloride is the salt form of Ethopropazine (Profenamine), a phenothiazine derivative with anticholinergic, antihistamine, and anti-adrenergic effects used in the treatment of Parkinson's disease, and acts as an AChE inhibitor by affecting the PAS active site.
Ethopropazine Hydrochloride
🥰Excellent
Catalog No. T21393Alias Profenamine HCl, Parsidol hydrochloride, Lysivane hydrochloride, Isothazine hydrochlorideCas No. 1094-08-2
Ethopropazine Hydrochloride is the salt form of Ethopropazine (Profenamine), a phenothiazine derivative with anticholinergic, antihistamine, and anti-adrenergic effects used in the treatment of Parkinson's disease, and acts as an AChE inhibitor by affecting the PAS active site.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $43 | In Stock | |
| 25 mg | $97 | In Stock | |
| 50 mg | $166 | In Stock | |
| 100 mg | $243 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $46 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Ethopropazine Hydrochloride is the salt form of Ethopropazine (Profenamine), a phenothiazine derivative with anticholinergic, antihistamine, and anti-adrenergic effects used in the treatment of Parkinson's disease, and acts as an AChE inhibitor by affecting the PAS active site. |
| Targets&IC50 | BCHE (human):1.6μM, AChE (human):1020μM |
| In vitro | Ellman’s method was used to assess the inhibitory activity of Ethopropazine Hydrochloride on cholinesterases, with human recombinant acetylcholinesterase (hAChE) and human plasma butyrylcholinesterase (hBChE) as target enzymes, and acetylthiocholine chloride (ATChCl) as the substrate. In a 96-well plate, enzyme solution, the chromogenic reagent DTNB, and different concentrations of Ethopropazine Hydrochloride (10 mM to 1 nM) were added sequentially. The reaction was initiated by adding 1 mM ATChCl, followed by incubation at 37°C for 5 minutes. Absorbance changes were measured at 412 nm. The Results showed that Ethopropazine Hydrochloride strongly inhibited hBChE (IC₅₀ = 1.6 μM), while its inhibitory effect on hAChE was weaker (IC₅₀ = 1020 μM), making it a highly efficient and selective BChE inhibitor [1]. |
| Alias | Profenamine HCl, Parsidol hydrochloride, Lysivane hydrochloride, Isothazine hydrochloride |
| Molecular Weight | 348.93 |
| Formula | C19H25ClN2S |
| Cas No. | 1094-08-2 |
| Smiles | Cl.S1C=2C=CC=CC2N(C=3C=CC=CC13)CC(N(CC)CC)C |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: < 1 mg/mL (insoluble), Sonication is recommended. DMSO: 20 mg/mL (57.32 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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