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Ethopropazine Hydrochloride

Name: Ethopropazine Hydrochloride
Brand: TargetMol
SKU: T21393
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21393Cas No. 1094-08-2

Alias Profenamine HCl, Parsidol hydrochloride, Lysivane hydrochloride, Isothazine hydrochloride

Ethopropazine Hydrochloride is the salt form of Ethopropazine (Profenamine), a phenothiazine derivative with anticholinergic, antihistamine, and anti-adrenergic effects used in the treatment of Parkinson's disease, and acts as an AChE inhibitor by affecting the PAS active site.

Ethopropazine Hydrochloride

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Purity: 98.25%

Catalog No. T21393Alias Profenamine HCl, Parsidol hydrochloride, Lysivane hydrochloride, Isothazine hydrochlorideCas No. 1094-08-2

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$40	-	In Stock
25 mg	$90	-	In Stock
50 mg	$156	-	In Stock
1 mL x 10 mM (in DMSO)	$44	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.25%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Ethopropazine Hydrochloride is the salt form of Ethopropazine (Profenamine), a phenothiazine derivative with anticholinergic, antihistamine, and anti-adrenergic effects used in the treatment of Parkinson's disease, and acts as an AChE inhibitor by affecting the PAS active site.
Targets&IC50	BCHE (human):1.6μM, AChE (human):1020μM
In vitro	Ellman’s method was used to assess the inhibitory activity of Ethopropazine Hydrochloride on cholinesterases, with human recombinant acetylcholinesterase (hAChE) and human plasma butyrylcholinesterase (hBChE) as target enzymes, and acetylthiocholine chloride (ATChCl) as the substrate. In a 96-well plate, enzyme solution, the chromogenic reagent DTNB, and different concentrations of Ethopropazine Hydrochloride (10 mM to 1 nM) were added sequentially. The reaction was initiated by adding 1 mM ATChCl, followed by incubation at 37°C for 5 minutes. Absorbance changes were measured at 412 nm. The Results showed that Ethopropazine Hydrochloride strongly inhibited hBChE (IC₅₀ = 1.6 μM), while its inhibitory effect on hAChE was weaker (IC₅₀ = 1020 μM), making it a highly efficient and selective BChE inhibitor [1].
Synonyms	Profenamine HCl, Parsidol hydrochloride, Lysivane hydrochloride, Isothazine hydrochloride

Chemical Properties

Molecular Weight	348.93
Formula	C₁₉H₂₅ClN₂S
Cas No.	1094-08-2
Smiles	Cl.S1C=2C=CC=CC2N(C=3C=CC=CC13)CC(N(CC)CC)C
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble), Sonication is recommended.

DMSO: 20 mg/mL (57.32 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.73 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8659 mL	14.3295 mL	28.6590 mL	143.2952 mL
5 mM	0.5732 mL	2.8659 mL	5.7318 mL	28.6590 mL
10 mM	0.2866 mL	1.4330 mL	2.8659 mL	14.3295 mL
20 mM	0.1433 mL	0.7165 mL	1.4330 mL	7.1648 mL
50 mM	0.0573 mL	0.2866 mL	0.5732 mL	2.8659 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc