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Aldoxorubicin hydrochloride

Name: Aldoxorubicin hydrochloride
Brand: TargetMol
SKU: T11090L1
Price: 57 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11090L1Cas No. 1361563-03-2

Alias Aldoxorubicin hydrochloride (1361644-26-9 Free base)

Aldoxorubicin hydrochloride is an albumin-binding prodrug of Doxorubicin, a DNA topoisomerase II inhibitor. Aldoxorubicin hydrochloride is released from albumin under acidic conditions. Aldoxorubicin hydrochloride exhibits potent antitumor activities in various cancer cell lines and in murine tumor models.

Aldoxorubicin hydrochloride

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Purity: 99.86%

Catalog No. T11090L1Alias Aldoxorubicin hydrochloride (1361644-26-9 Free base)Cas No. 1361563-03-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$57	In Stock	In Stock
2 mg	$77	In Stock	In Stock
5 mg	$117	In Stock	In Stock
10 mg	$155	In Stock	In Stock
25 mg	$313	In Stock	In Stock
50 mg	$466	In Stock	In Stock
100 mg	$683	-	In Stock
500 mg	$1,450	-	In Stock
1 mL x 10 mM (in DMSO)	$211	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.86%

Appearance:Solid

Color:Red

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Aldoxorubicin hydrochloride is an albumin-binding prodrug of Doxorubicin, a DNA topoisomerase II inhibitor. Aldoxorubicin hydrochloride is released from albumin under acidic conditions. Aldoxorubicin hydrochloride exhibits potent antitumor activities in various cancer cell lines and in murine tumor models.
In vitro	Aldoxorubicin hydrochloride (0.27 to 2.16 μM) inhibits formation of blood vessel and reduces growth of multiple myeloma cell in a pH-dependent fashion[1].
In vivo	Aldoxorubicin hydrochloride (10.8 mg/kg, i.v.) significantly reduces tumor volumes and IgG levels by day 28, showing high tolerability with a 90% survival rate in mice with LAGκ-1A tumors [1]. It demonstrates a favorable safety profile at doses up to 260 mg/mL doxorubicin equivalents, effectively inducing tumor regression in breast cancer, small cell lung cancer, and sarcoma during a phase I study [2]. Additionally, it outperforms doxorubicin in murine renal cell carcinoma and breast carcinoma xenograft models [3].
Synonyms	Aldoxorubicin hydrochloride (1361644-26-9 Free base)

Chemical Properties

Molecular Weight	787.21
Formula	C₃₇H₄₃ClN₄O₁₃
Cas No.	1361563-03-2
Smiles	OC=1C2=C([C@@H](O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C[C@@](\C(=N\NC(CCCCCN4C(=O)C=CC4=O)=O)\CO)(O)C2)C(O)=C5C1C(=O)C=6C(C5=O)=C(OC)C=CC6.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 127.5 mg/mL (161.96 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2703 mL	6.3515 mL	12.7031 mL	63.5155 mL
5 mM	0.2541 mL	1.2703 mL	2.5406 mL	12.7031 mL
10 mM	0.1270 mL	0.6352 mL	1.2703 mL	6.3515 mL
20 mM	0.0635 mL	0.3176 mL	0.6352 mL	3.1758 mL
50 mM	0.0254 mL	0.1270 mL	0.2541 mL	1.2703 mL
100 mM	0.0127 mL	0.0635 mL	0.1270 mL	0.6352 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc