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Anti-JAK3 Antibody (5S507)

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Catalog No. TMAC-02278

Anti-JAK3 Antibody (5S507) is a Rabbit antibody targeting JAK3. Anti-JAK3 Antibody (5S507) can be used in WB,IHC,ICC.

Anti-JAK3 Antibody (5S507)

Anti-JAK3 Antibody (5S507)

😃Good
Catalog No. TMAC-02278
Anti-JAK3 Antibody (5S507) is a Rabbit antibody targeting JAK3. Anti-JAK3 Antibody (5S507) can be used in WB,IHC,ICC.
Pack SizePriceAvailabilityQuantity
50 μL$2967-10 days
100 μL$4987-10 days
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Product Introduction

Bioactivity
Description
Anti-JAK3 Antibody (5S507) is a Rabbit antibody targeting JAK3. Anti-JAK3 Antibody (5S507) can be used in WB,IHC,ICC.
Ig Type
IgG
Reactivity
Human
Application
Recommended Dose
WB: 1:500-1000; IHC: 1:50-200; ICC: 1:50-100
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundNon-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein
Antigen Species
Recombinant Protein
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 125 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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