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Anti-JAK3 Antibody (5S507)
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Catalog No. TMAC-02278
Alias Tyrosine-protein kinase JAK3, L-JAK, Leukocyte janus kinase, Janus kinase 3, JAK-3, EC 2.7.10.2
Anti-JAK3 Antibody (5S507) is a Rabbit antibody targeting JAK3. Anti-JAK3 Antibody (5S507) can be used in ICC,IHC,WB.
Anti-JAK3 Antibody (5S507)
Anti-JAK3 Antibody (5S507)
😃Good
Catalog No. TMAC-02278Alias Tyrosine-protein kinase JAK3, L-JAK, Leukocyte janus kinase, Janus kinase 3, JAK-3, EC 2.7.10.2
Anti-JAK3 Antibody (5S507) is a Rabbit antibody targeting JAK3. Anti-JAK3 Antibody (5S507) can be used in ICC,IHC,WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $296 | 7-10 days | |
| 100 μL | $498 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Anti-JAK3 Antibody (5S507) is a Rabbit antibody targeting JAK3. Anti-JAK3 Antibody (5S507) can be used in ICC,IHC,WB. |
| Synonyms | Tyrosine-protein kinase JAK3, L-JAK, Leukocyte janus kinase, Janus kinase 3, JAK-3, EC 2.7.10.2 |
| Ig Type | IgG |
| Clone | 5S507 |
| Reactivity | Human |
| Verified Activity | 1. Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-JAK3 antibody. Counter stained with hematoxylin. 2. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-JAK3 antibody. Counter stained with hematoxylin. 3. ICC staining JAK3 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. |
| Application | |
| Recommended Dose | WB: 1:500-1000; IHC: 1:50-200; ICC: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 125 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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