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Pomaglumetad methionil hydrochloride

Catalog No. T61972 CAS 635318-26-2

Synonyms: LY2140023 hydrochloride

Pomaglumetad methionine hydrochloride (LY2140023 hydrochloride) is a methionine prodrug of LY404039 with oral activity. LY404039 is a selective mGlu2/3 receptor agonist. Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) has research value in schizophrenia.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pomaglumetad methionil hydrochloride Chemical Structure

Pomaglumetad methionil hydrochloride, CAS 635318-26-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 212.00
5 mg	In stock	$ 538.00
10 mg	In stock	$ 778.00
25 mg	In stock	$ 1,180.00
50 mg	In stock	$ 1,620.00

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Purity: 99.01%

Biological Description

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Storage & Solubility Information

Description	Pomaglumetad methionine hydrochloride (LY2140023 hydrochloride) is a methionine prodrug of LY404039 with oral activity. LY404039 is a selective mGlu2/3 receptor agonist. Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) has research value in schizophrenia.
In vitro	Pomaglumetad methionil (LY2140023) is a high-affinity peptide transporter 1 (PEPT1) substrate with a Km value of ~30 µM. LY2140023 is active against [14C]Gly-Sar with an IC50 value of 0.018 mM[2].
In vivo	Pomaglumetad methionil (LY2140023; orally; 3-300 mg/kg; once daily for 7 days) dose-dependent increases the levels of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) [1].

Synonyms	LY2140023 hydrochloride
Molecular Weight	402.87
Formula	C12H19ClN2O7S2
CAS No.	635318-26-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (55.8 mM), Sonication is recommended.

References and Literature

1. Lowe S, et al. Effects of a novel mGlu₂/₃ receptor agonist prodrug, LY2140023 monohydrate, on central monoamine turnover as determined in human and rat cerebrospinal fluid. Psychopharmacology (Berl). 2012 Feb;219(4):959-70. 2. Y Anne Pak, et al. In Vitro and Clinical Evaluations of the Drug-Drug Interaction Potential of a Metabotropic Glutamate 2/3 Receptor Agonist Prodrug with Intestinal Peptide Transporter 1. Drug Metab Dispos. 2017 Feb;45(2):137-144.

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Keywords

Pomaglumetad methionil hydrochloride 635318-26-2 Neuroscience GluR LY2140023 hydrochloride Pomaglumetad methionil Hydrochloride LY 2140023 Hydrochloride LY2140023 Hydrochloride LY-2140023 Hydrochloride inhibitor inhibit

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