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L-741626

Name: L-741626
Brand: TargetMol
SKU: T15686
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15686Cas No. 81226-60-0

Alias 3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole

L-741626 (3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole) is a selective antagonist of D2 dopamine receptor (Ki: 2.4, 100, and 220 nM for human D2, D3 and D4 receptors respectively).

L-741626

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Purity: 98.57%

Catalog No. T15686Alias 3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indoleCas No. 81226-60-0

L-741626 (3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole) is a selective antagonist of D2 dopamine receptor (Ki: 2.4, 100, and 220 nM for human D2, D3 and D4 receptors respectively).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$48	In Stock	In Stock
25 mg	$94	In Stock	In Stock
50 mg	$173	In Stock	In Stock
100 mg	$278	In Stock	In Stock
200 mg	$397	-	In Stock
1 mL x 10 mM (in DMSO)	$31	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:98.57%

Appearance:solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	L-741626 (3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole) is a selective antagonist of D2 dopamine receptor (Ki: 2.4, 100, and 220 nM for human D2, D3 and D4 receptors respectively).
Targets&IC50	D2 receptor (human):(ki)2.4 nM, D3 receptor (human):100 nM(ki), D4 receptor (human):220 nM(ki)
In vitro	L-741626 is an effective antagonist (EC50 (D2)=4.46 nM) with some D2 selectivity (EC50 (D3)=90.4 nM), in the functional assay. L-741626 is prepared by literature methods (Ki (D2)=11.2 nM). L-741626 also shows a D3/D2 and D4/D2 selectivity ratio of 15-fold and 136-fold, respectively. Intrinsic activities using inhibition of quinpirole stimulation of mitogenesis in human dopamine D2 or D3 receptors transfected into Chinese hamster ovary (CHO) cells, in a functional assay [2].
In vivo	In pramipexole-trained male Sprague Dawley rats, L-741626 (1.0 mg/kg; i.h.) is effective at shifting to the right the pramipexole dose-response curve [3]. Coadministration Cocaine with the D2 antagonist L-741626 (3 mg/kg; i.p.; 15 min before Cocaine) for 5 days decreases the Cocaine-induced enhance in microglial TNF-α production in adult mice [4].
Synonyms	3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole

Chemical Properties

Molecular Weight	340.85
Formula	C₂₀H₂₁ClN₂O
Cas No.	81226-60-0
Smiles	OC1(CCN(Cc2c[nH]c3ccccc23)CC1)c1ccc(Cl)cc1
Relative Density.	1.311g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (117.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.87 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9338 mL	14.6692 mL	29.3384 mL	146.6921 mL
5 mM	0.5868 mL	2.9338 mL	5.8677 mL	29.3384 mL
10 mM	0.2934 mL	1.4669 mL	2.9338 mL	14.6692 mL
20 mM	0.1467 mL	0.7335 mL	1.4669 mL	7.3346 mL
50 mM	0.0587 mL	0.2934 mL	0.5868 mL	2.9338 mL
100 mM	0.0293 mL	0.1467 mL	0.2934 mL	1.4669 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc