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TM2-115

Name: TM2-115
Brand: TargetMol
SKU: T9004
Price: 61 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9004Cas No. 1197196-47-6

TM2-115 is a inhibitor of malaria parasite histone methyltransferases that results in rapid and irreversible parasite death [1].

TM2-115

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Purity: 97.67%

Catalog No. T9004Cas No. 1197196-47-6

TM2-115 is a inhibitor of malaria parasite histone methyltransferases that results in rapid and irreversible parasite death [1].

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$61	In Stock	In Stock
5 mg	$147	In Stock	In Stock
10 mg	$239	-	In Stock
25 mg	$446	-	In Stock
50 mg	$653	-	In Stock
1 mL x 10 mM (in DMSO)	$159	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.67%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

TM2-115 AI Summary

TM2-115 exhibits a broad spectrum of bioactivity with inhibitory effects on diverse targets including human flap endonuclease 1 (FEN1), histone lysine methyltransferase G9a, mammalian selenoprotein thioredoxin reductase 1 (TrxR1), and human tyrosyl-DNA phosphodiesterase 1 (TDP1). It further induces synthetic lethality in tumor cells producing 2HG. The compound shows antimalarial activity, effectively reducing parasitemia in Plasmodium berghei ANKA-infected mice at a dosage of 40 mg/kg. Additionally, it has potent antiplasmodial activity against drug-sensitive Plasmodium falciparum 3D7 with an IC50 of 43.0 nM and an EC50 of 100.0 nM. Notably, TM2-115 demonstrates poor selectivity for human G9a with an IC50 value greater than 1000.0 nM, and despite its favorable selectivity ratio against Plasmodium falciparum 3D7, it presents cytotoxicity concerns in human HepG2 cells with an IC50 of 4700.0 nM, yielding a selectivity ratio of 110.1..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

TM2-115 is a inhibitor of malaria parasite histone methyltransferases that results in rapid and irreversible parasite death [1].

Chemical Properties

Molecular Weight	490.64
Formula	C₂₈H₃₈N₆O₂
Cas No.	1197196-47-6
Smiles	N(C=1C2=C(N=C(N1)N3CCN(C)CCC3)C=C(OCC4=CC=CC=C4)C(OC)=C2)C5CCN(C)CC5
Relative Density.	1.188 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (91.72 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.08 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0382 mL	10.1908 mL	20.3815 mL	101.9077 mL
5 mM	0.4076 mL	2.0382 mL	4.0763 mL	20.3815 mL
10 mM	0.2038 mL	1.0191 mL	2.0382 mL	10.1908 mL
20 mM	0.1019 mL	0.5095 mL	1.0191 mL	5.0954 mL
50 mM	0.0408 mL	0.2038 mL	0.4076 mL	2.0382 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc