IL-1RA Protein, Human, Recombinant V2

Name: IL-1RA Protein, Human, Recombinant V2
Brand: TargetMol
SKU: TMPY-00853U
Rating: 4.5 (1 reviews)

(Synonyms: MVCD4, IRAP, interleukin 1 receptor antagonist, IL-1RN, IL-1ra3, IL-1ra, IL1RA, IL1F3, ICIL-1RA, DIRA) Copy Product Info

Synonyms: MVCD4, IRAP, interleukin 1 receptor antagonist, IL-1RN, IL-1ra3, IL-1ra, IL1RA, IL1F3, ICIL-1RA, DIRA

Catalog No. TMPY-00853U Copy Product Info

IL-1RA Protein, Human, Recombinant V2 is expressed in E. coli. The accession number is P18510.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$33	7-10 days	7-10 days
10 µg	$48	7-10 days	7-10 days
20 µg	$75	7-10 days	7-10 days
50 µg	$139	7-10 days	7-10 days
100 µg	$233	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Immobilized Human AXL-His at 10 μg/ml (100 μl/well) can bind Human GAS6-His.: Biotinylated by NHS-biotin prior to testing The ED50 of Recombinant Human GAS6-His* is 0.04466 μg/ml. (Regularly tested)
Description	IL-1RA Protein, Human, Recombinant V2 is expressed in E. coli. The accession number is P18510.
Species	Human
Expression System	E. coli
Tag	Tag Free
Accession Number	P18510
Construction	Arg26-Glu177
Protein Purity	> 95% as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 8% Trehalose, 4% Mannitol, 50 mM NaCl, 0.05% Tween80, pH7.5.
Reconstitution	Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/mL. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	MVCD4, IRAP, interleukin 1 receptor antagonist, IL-1RN, IL-1ra3, IL-1ra, IL1RA, IL1F3, ICIL-1RA, DIRA
Research Background	Interleukin-1 Receptor Antagonist (IL-1RN) is a member of the IL-1 family. Endogenous IL-1RN is produced in numerous animal disease models as well as in human autoimmune and chronic inflammatory diseases. It binds to IL-1 receptors in competition with IL-1, but does not elicit intracellular response from this binding. Its role in counteracting the proinflammatory effects of IL-1 is being studied by numerous research groups. IL-4 and IL-13 have been shown to amplify the stimulatory effect of IL1-beta on the production of soluble and intracellular forms of IL-1RN. The regulated expression of IL-1RN in various cell types has been shown to be influenced by cytokines. In synovial fibroblasts, IL-1, TNF-alpha, or PDGF markedly enhances the synthesis of IL-1RN.

Chemical Properties

Molecular Weight

17.26 kDa (Predicted); 18 kDa (Reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.