Powder: -20°C for 3 years | In solvent: -80°C for 1 year
OTUB1/USP8-IN-1 HCL is a potent dual inhibitor of OTUB1 and USP8 with potential antitumour activity, inhibiting both OTUB1 and USP8. OTUB1/USP8-IN-1 may be used in the study of leukaemia.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | Inquiry | $ 162.00 | |
5 mg | Inquiry | $ 357.00 | |
10 mg | Inquiry | $ 429.00 | |
25 mg | Inquiry | $ 987.00 | |
50 mg | Inquiry | $ 1,520.00 | |
100 mg | Inquiry | $ 1,980.00 |
Description | OTUB1/USP8-IN-1 HCL is a potent dual inhibitor of OTUB1 and USP8 with potential antitumour activity, inhibiting both OTUB1 and USP8. OTUB1/USP8-IN-1 may be used in the study of leukaemia. |
Targets&IC50 | USP8:0.28 nM, OTUB1:0.17 nM |
In vitro | OTUB1/USP8-IN-1 (compound 61) exhibits antiproliferative effects in KRAS-WT (H1975, EBC-1, H1703) and KRAS-mutated (H23, A549) NSCLC cell lines when treated with concentrations ranging from 10 nM to 10 μM for 72 hours[1]. Additionally, treatment with OTUB1/USP8-IN-1 at 500 nM for 24 hours leads to a decrease in protein levels of both UBE2N and EGFR in H1975 cells[1]. |
In vivo | In the H1975 xenograft mouse model, treatment with OTUB1/USP8-IN-1 (compound 61) at concentrations ranging from 10 nM to 10 μM for 72 hours results in a decrease in tumor burden[1]. |
Synonyms | OTUB1/USP8-IN-1 HCl(2858800-98-1 Free base) |
Molecular Weight | 463.29 |
Formula | C22H17Cl2FN2O4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
OTUB1/USP8-IN-1 HCl Cell Cycle/Checkpoint DNA Damage/DNA Repair Ubiquitination DUB OTUB1/USP8-IN-1 HCl(2858800-98-1 Free base) OTUB1/USP8IN1HCL(2858800981Freebase) inhibitor inhibit