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Antitumor agent-149

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Catalog No. T85707Cas No. 2368983-54-2

Antitumor agent-149 (Compound 3), an analogue of Echinomycin, inhibits HIF-1α-mediated transcription, induces cancer cell apoptosis, and suppresses tumor growth in the SW620 xenograft mice model [1].

Antitumor agent-149

Antitumor agent-149

😃Good
Catalog No. T85707Cas No. 2368983-54-2
Antitumor agent-149 (Compound 3), an analogue of Echinomycin, inhibits HIF-1α-mediated transcription, induces cancer cell apoptosis, and suppresses tumor growth in the SW620 xenograft mice model [1].
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Product Introduction

Bioactivity
Description
Antitumor agent-149 (Compound 3), an analogue of Echinomycin, inhibits HIF-1α-mediated transcription, induces cancer cell apoptosis, and suppresses tumor growth in the SW620 xenograft mice model [1].
In vitro
Antitumor agent-149 exhibits cytotoxicity against SW620 and MIA PaCa-2 cells, with IC₅₀ values of 0.85 nM and 1.4 nM, respectively [1].
Chemical Properties
Molecular Weight1085.19
FormulaC52H64N10O14S
Cas No.2368983-54-2
SmilesC(N[C@@H]1COC(=O)[C@H](C(C)C)N(C)C(=O)[C@@]2(CSC[C@](N(C)C(=O)[C@H](C)NC1=O)(C(=O)N(C)[C@@H](C(C)C)C(=O)OC[C@@H](NC(=O)C3=NC4=C(C=C3O)C=CC=C4)C(=O)N[C@@H](C)C(=O)N2C)[H])[H])(=O)C5=NC6=C(C=C5O)C=CC=C6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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