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Anti-SCARB1/Scavenger Receptor BI Antibody (8A412)
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Catalog No. TMAB-12560
Anti-SCARB1/Scavenger Receptor BI Antibody (8A412) is a Rabbit antibody targeting SCARB1/Scavenger Receptor BI. Anti-SCARB1/Scavenger Receptor BI Antibody (8A412) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF.
Anti-SCARB1/Scavenger Receptor BI Antibody (8A412)
Anti-SCARB1/Scavenger Receptor BI Antibody (8A412)
😃Good
Catalog No. TMAB-12560
Anti-SCARB1/Scavenger Receptor BI Antibody (8A412) is a Rabbit antibody targeting SCARB1/Scavenger Receptor BI. Anti-SCARB1/Scavenger Receptor BI Antibody (8A412) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $149 | 7-10 days | 7-10 days | |
| 50 μL | $264 | 7-10 days | 7-10 days | |
| 100 μL | $470 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-SCARB1/Scavenger Receptor BI Antibody (8A412) is a Rabbit antibody targeting SCARB1/Scavenger Receptor BI. Anti-SCARB1/Scavenger Receptor BI Antibody (8A412) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF. |
| Ig Type | IgG |
| Clone | 8A412 |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:200-500; ICC/IF: 1:50-200; IF: 1:100-500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. Membrane, caveola; Multi-pass membrane protein. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae. |
| Tissue Specificity | Widely expressed. The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BI (Scavenger Receptor BI) protein binds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by a distinct mechanism. In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland. Scavenging Receptor SR-BI plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer. |
| Immunogen | KLH conjugated synthetic peptide: human SCARB1/Scavenger Receptor BI |
| Antigen Species | Human |
| Gene Name | SCARB1 |
| Gene ID | |
| Protein Name | Scavenger receptor class B member 1 |
| Uniprot ID | |
| Function | Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester. |
| Molecular Weight | Theoretical: 61 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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