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L 888607

Name: L 888607
Brand: TargetMol
SKU: T15828
Rating: 4.5 (1 reviews)

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Catalog No. T15828Cas No. 860033-06-3

L 888607 is an effective and selective CRTH2 agonist (Ki: 0.8 nM).

L 888607

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Catalog No. T15828Cas No. 860033-06-3

L 888607 is an effective and selective CRTH2 agonist (Ki: 0.8 nM).

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$316	7-10 days	7-10 days
1 mL x 10 mM (in DMSO)	$313	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	L 888607 is an effective and selective CRTH2 agonist (Ki: 0.8 nM).
Targets&IC50	DP/DP1 receptor:2331 nM (ki), TP receptor:283 nM (ki), EP2 receptor:8748 nM (ki), EP4 receptor:4634 nM (ki), IP receptor:14434 nM (ki), EP3 III receptor:1260 nM (ki), FPR:10018 nM (ki), CRTH2/DP2 receptor:0.8 nM (ki)

Chemical Properties

Molecular Weight	375.84
Formula	C₁₉H₁₅ClFNO₂S
Cas No.	860033-06-3
Smiles	OC(=O)C[C@@H]1CCn2c1c(Sc1ccc(Cl)cc1)c1ccc(F)cc21
Relative Density.	1.46 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (399.11 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (8.78 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6607 mL	13.3035 mL	26.6071 mL	133.0353 mL
5 mM	0.5321 mL	2.6607 mL	5.3214 mL	26.6071 mL
10 mM	0.2661 mL	1.3304 mL	2.6607 mL	13.3035 mL
20 mM	0.1330 mL	0.6652 mL	1.3304 mL	6.6518 mL
50 mM	0.0532 mL	0.2661 mL	0.5321 mL	2.6607 mL
100 mM	0.0266 mL	0.1330 mL	0.2661 mL	1.3304 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc