Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PARP1-IN-10 (compound 12c) is a highly potent and non-cytotoxic PARP1 inhibitor, displaying an in vitro IC50 value of 50.62 nM. This compound effectively induces cell cycle arrest at the G2/M phase and apoptosis, while also significantly augmenting the cytotoxic effects of temozolomide (TMZ) [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | PARP1-IN-10 (compound 12c) is a highly potent and non-cytotoxic PARP1 inhibitor, displaying an in vitro IC50 value of 50.62 nM. This compound effectively induces cell cycle arrest at the G2/M phase and apoptosis, while also significantly augmenting the cytotoxic effects of temozolomide (TMZ) [1]. |
In vitro | PARP1-IN-10 (compound 12c) demonstrated no cytotoxicity at a concentration of 10 μM over 48 hours against NCI-60 human tumor cell lines. It effectively inhibited the MDA-MB-436 cell line, presenting an IC50 value of 3.73 μM. Furthermore, administration of PARP1-IN-10 at concentrations of 1 and 3.73 μM for 48 hours induced cell cycle arrest at the G2/M phase in a dose-dependent manner. Additionally, at a lower dose of 0.5 μM for 48 hours, PARP1-IN-10 significantly enhanced the anti-proliferative effect of temozolomide (TMZ) in A549 cell lines, making it approximately 7 times more effective than TMZ alone (reducing the IC50 from 24.2 μM to 3.64 μM). These results, encompassing cytotoxicity assays, cell cycle, and apoptosis analysis, underline the potential of PARP1-IN-10 as a therapeutic agent, specific in its action and synergistic with existing treatments like TMZ. |
Molecular Weight | 385.41 |
Formula | C20H23N3O5 |
CAS No. | 2494001-21-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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PARP1-IN-10 2494001-21-5 inhibitor inhibit