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1-Deoxynojirimycin

Name: 1-Deoxynojirimycin
Brand: TargetMol
SKU: T3675
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3675Cas No. 19130-96-2

Alias Moranoline, moranolin, Duvoglustat

1-Deoxynojirimycin (Moranoline) is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.

1-Deoxynojirimycin

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Purity: 99.98%

Catalog No. T3675Alias Moranoline, moranolin, DuvoglustatCas No. 19130-96-2

1-Deoxynojirimycin (Moranoline) is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$38	In Stock	In Stock
5 mg	$56	In Stock	In Stock
10 mg	$72	In Stock	In Stock
25 mg	$150	In Stock	In Stock
50 mg	$275	In Stock	In Stock
100 mg	$357	In Stock	In Stock
500 mg	$859	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$55	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.98%

Color:White

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COA HNMR LCMS

Product Introduction

1-Deoxynojirimycin AI Summary

1-Deoxynojirimycin exhibits various bioactivities related to the inhibition of carbohydrate-metabolizing enzymes. It shows potent inhibitory effects on alpha-glucosidases from different sources, including rice, rat intestinal maltase, and human lysosomal alpha-glucosidase, with IC50 values as low as 14.0 nM, indicating high potency. Additionally, 1-Deoxynojirimycin inhibits alpha-galactosidase from Aspergillus niger and beta-glucosidase from almonds. Despite its broad spectrum of inhibition across multiple enzymes, it shows relatively weaker activity against beta-galactosidase from Escherichia coli and bovine liver, with IC50 values greater than 300,000 nM. The compound also exhibits strong inhibition of rat intestinal sucrase and human lysosomal alpha-glucosidase, with Ki values of 24.0 nM and 150.0 nM, respectively. Furthermore, studies highlight that 1-Deoxynojirimycin does not significantly affect HIV-1 induced cytopathogenicity and shows no antiviral activity against SARS-CoV-2, suggesting its primary utility lies in modulating enzyme activities related to carbohydrate metabolism..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1-Deoxynojirimycin (Moranoline) is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.
Synonyms	Moranoline, moranolin, Duvoglustat

Chemical Properties

Molecular Weight	163.17
Formula	C₆H₁₃NO₄
Cas No.	19130-96-2
Smiles	OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Relative Density.	1.456 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 17.86 mg/mL (109.46 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.1286 mL	30.6429 mL	61.2858 mL	306.4289 mL
5 mM	1.2257 mL	6.1286 mL	12.2572 mL	61.2858 mL
10 mM	0.6129 mL	3.0643 mL	6.1286 mL	30.6429 mL
20 mM	0.3064 mL	1.5321 mL	3.0643 mL	15.3214 mL
50 mM	0.1226 mL	0.6129 mL	1.2257 mL	6.1286 mL
100 mM	0.0613 mL	0.3064 mL	0.6129 mL	3.0643 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc