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PDE9-IN-(S)-C33

Name: PDE9-IN-(S)-C33
Brand: TargetMol
SKU: T28352
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28352Cas No. 2066488-39-7

PDE9-IN-(S)-C33 ((S)-C33) is a potent and selective inhibitor of PDE9 (IC50 = 11 nM). PDE9-IN-(S)-C33 can be used for central nervous system diseases and diabetes research.

PDE9-IN-(S)-C33

🥰Excellent

Purity: 98.75%

Catalog No. T28352Cas No. 2066488-39-7

PDE9-IN-(S)-C33 ((S)-C33) is a potent and selective inhibitor of PDE9 (IC50 = 11 nM). PDE9-IN-(S)-C33 can be used for central nervous system diseases and diabetes research.

Pack Size	Price	Availability
1 mg	$33	In Stock
5 mg	$67	In Stock
10 mg	$95	In Stock
25 mg	$155	In Stock
50 mg	$230	In Stock
100 mg	$343	In Stock
200 mg	$489	In Stock
1 mL x 10 mM (in DMSO)	$76	In Stock

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Purity:98.75%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	PDE9-IN-(S)-C33 ((S)-C33) is a potent and selective inhibitor of PDE9 (IC50 = 11 nM). PDE9-IN-(S)-C33 can be used for central nervous system diseases and diabetes research.
Targets&IC50	PDE2A:2.4 ± 0.5 μM, PDE1B:554 ± 64 nM, PDE4D2:1.3 ± 0.1 μM, PDE10A1:2.3 ± 0.3 μM, PDE5A1:366 ± 38 nM, PDE9A:11 ± 4 nM

Chemical Properties

Molecular Weight	357.84
Formula	C₁₈H₂₀ClN₅O
Cas No.	2066488-39-7
Smiles	O=C1C2=C(N(N=C2)C3CCCC3)NC(N[C@@H](C)C4=CC=C(Cl)C=C4)=N1
Relative Density.	1.46 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (265.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7945 mL	13.9727 mL	27.9455 mL	139.7273 mL
5 mM	0.5589 mL	2.7945 mL	5.5891 mL	27.9455 mL
10 mM	0.2795 mL	1.3973 mL	2.7945 mL	13.9727 mL
20 mM	0.1397 mL	0.6986 mL	1.3973 mL	6.9864 mL
50 mM	0.0559 mL	0.2795 mL	0.5589 mL	2.7945 mL
100 mM	0.0279 mL	0.1397 mL	0.2795 mL	1.3973 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc