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Bupivacaine hydrochloride monohydrate

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Catalog No. T80641Cas No. 73360-54-0

Bupivacaine hydrochloride monohydrate is a potent NMDA receptor inhibitor of sodium, L-calcium, and potassium channels.Bupivacaine hydrochloride monohydrate inhibits SCN5A channels and is commonly used in the study of chronic pain.

Bupivacaine hydrochloride monohydrate
Other Forms of Bupivacaine hydrochloride monohydrate:

Bupivacaine hydrochloride monohydrate

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Purity: 99.91%
Catalog No. T80641Cas No. 73360-54-0
Bupivacaine hydrochloride monohydrate is a potent NMDA receptor inhibitor of sodium, L-calcium, and potassium channels.Bupivacaine hydrochloride monohydrate inhibits SCN5A channels and is commonly used in the study of chronic pain.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$117In StockIn Stock
5 mg$290In StockIn Stock
10 mg$415In StockIn Stock
25 mg$648In StockIn Stock
50 mg$893In StockIn Stock
100 mg$1,180-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.91%
Appearance:Solid
Color:White
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
Bupivacaine hydrochloride monohydrate is a potent NMDA receptor inhibitor of sodium, L-calcium, and potassium channels.Bupivacaine hydrochloride monohydrate inhibits SCN5A channels and is commonly used in the study of chronic pain.
Targets&IC50
SCN5A channel:2.18±0.16 μM
In vitro
Bupivacaine hydrochloride monohydrate inhibits synaptic transmission mediated by NMDA receptors in the spinal dorsal horn, which is an area closely associated with central sensitization[1]. Bupivacaine hydrochloride monohydrate affects the voltage dependence of channel activation and steady-state inactivation by shifting the half-maximal activation/inactivation membrane potential to a slightly more negative membrane potential.In the inactivated state, the SCN5A channel shows slight sensitivity to Bupivacaine hydrochloride monohydrate (IC50=2.18±0.16 μM)[3]. Bupivacaine hydrochloride monohydrate reversibly inhibits SK2 channels in a dose-dependent manner, with an IC50 of 16.5 μM[2].
Chemical Properties
Molecular Weight342.9
FormulaC18H31ClN2O2
Cas No.73360-54-0
SmilesCl.O=C(NC=1C(=CC=CC1C)C)C2N(CCCC)CCCC2.O
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SodiumChannelSodium ChannelPotassiumChannelPotassium ChannelNMDA receptorCalciumChannelCalcium Channel
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