Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bupivacaine hydrochloride monohydrate is a potent NMDA receptor inhibitor of sodium, L-calcium, and potassium channels.Bupivacaine hydrochloride monohydrate inhibits SCN5A channels and is commonly used in the study of chronic pain.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 195.00 | |
5 mg | In stock | $ 483.00 | |
10 mg | In stock | $ 692.00 | |
25 mg | In stock | $ 1,080.00 | |
50 mg | In stock | $ 1,490.00 | |
100 mg | In stock | $ 1,970.00 | |
500 mg | In stock | $ 3,930.00 |
Description | Bupivacaine hydrochloride monohydrate is a potent NMDA receptor inhibitor of sodium, L-calcium, and potassium channels.Bupivacaine hydrochloride monohydrate inhibits SCN5A channels and is commonly used in the study of chronic pain. |
Targets&IC50 | SCN5A channel:2.18±0.16 μM |
In vitro | Bupivacaine hydrochloride monohydrate inhibits synaptic transmission mediated by NMDA receptors in the spinal dorsal horn, which is an area closely associated with central sensitization[1]. Bupivacaine hydrochloride monohydrate affects the voltage dependence of channel activation and steady-state inactivation by shifting the half-maximal activation/inactivation membrane potential to a slightly more negative membrane potential.In the inactivated state, the SCN5A channel shows slight sensitivity to Bupivacaine hydrochloride monohydrate (IC50=2.18±0.16 μM)[3]. Bupivacaine hydrochloride monohydrate reversibly inhibits SK2 channels in a dose-dependent manner, with an IC50 of 16.5 μM[2]. |
Molecular Weight | 342.9 |
Formula | C18H31ClN2O2 |
CAS No. | 73360-54-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Bupivacaine hydrochloride monohydrate 73360-54-0 Membrane transporter/Ion channel Metabolism Neuroscience Calcium Channel Sodium Channel Potassium Channel NMDAR inhibitor inhibit