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Anti-TCL3/HOX11 Polyclonal Antibody

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Catalog No. TMAB-13431

Anti-TCL3/HOX11 Polyclonal Antibody is a Rabbit antibody targeting TCL3/HOX11. Anti-TCL3/HOX11 Polyclonal Antibody can be used in WB.

Anti-TCL3/HOX11 Polyclonal Antibody

Anti-TCL3/HOX11 Polyclonal Antibody

😃Good
Catalog No. TMAB-13431
Anti-TCL3/HOX11 Polyclonal Antibody is a Rabbit antibody targeting TCL3/HOX11. Anti-TCL3/HOX11 Polyclonal Antibody can be used in WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2227-10 days7-10 days
100 μL$3737-10 days7-10 days
200 μL$5277-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-TCL3/HOX11 Polyclonal Antibody is a Rabbit antibody targeting TCL3/HOX11. Anti-TCL3/HOX11 Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human,Mouse (predicted:Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep)
Application
WB
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationNucleus.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThe Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. The Hox11 gene, termed an orphan homeobox gene, as it is located outside of the four mammalian Hox clusters, is a DNA-binding nuclear transcription factor. The human Hox11 gene maps to chromosome 10q24 and has been implicated in the chromosomal translocation t(7;10)(q24;q11) that occurs in T-cell acute lymphoblastic leukemia (T-ALL). The t(7:10) translocation occurs between the Hox11 gene and the T-cell receptor (TCR) delta-chain gene and is a result of aberrant physiological recombinational events at the early stages of T-cell development. The Hox11 gene is normally expressed in the splanchnic anlage arising from the splanchnic mesoderm. Homozygous Hox11-deficient mice have no spleen, while all other splanchnic derivatives develop normally. Spleen development starts and proceeds normally in Hox11-deficient mice to a specific stage of embryogenesis, when the spleen anlage becomes fully absorbed.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human TCL3/HOX11
Antigen Species
Human
Gene Name
TLX1
Gene ID
3195
Protein Name
T-cell leukemia homeobox protein 1
Uniprot ID
P31314
Function
Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.
Chemical Properties
Molecular WeightTheoretical: 34 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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