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Anti-Phospho-AMPK beta 1+AMPK beta 2 (Ser182/Ser184) Polyclonal Antibody
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Catalog No. TMAB-10317
Anti-Phospho-AMPK beta 1+AMPK beta 2 (Ser182/Ser184) Polyclonal Antibody is a Rabbit antibody targeting Phospho-AMPK beta 1+AMPK beta 2 (Ser182/Ser184). Anti-Phospho-AMPK beta 1+AMPK beta 2 (Ser182/Ser184) Polyclonal Antibody can be used in IHC-P,IHC-Fr,ICC/IF,IF,FCM.
Anti-Phospho-AMPK beta 1+AMPK beta 2 (Ser182/Ser184) Polyclonal Antibody
Anti-Phospho-AMPK beta 1+AMPK beta 2 (Ser182/Ser184) Polyclonal Antibody
😃Good
Catalog No. TMAB-10317
Anti-Phospho-AMPK beta 1+AMPK beta 2 (Ser182/Ser184) Polyclonal Antibody is a Rabbit antibody targeting Phospho-AMPK beta 1+AMPK beta 2 (Ser182/Ser184). Anti-Phospho-AMPK beta 1+AMPK beta 2 (Ser182/Ser184) Polyclonal Antibody can be used in IHC-P,IHC-Fr,ICC/IF,IF,FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-AMPK beta 1+AMPK beta 2 (Ser182/Ser184) Polyclonal Antibody is a Rabbit antibody targeting Phospho-AMPK beta 1+AMPK beta 2 (Ser182/Ser184). Anti-Phospho-AMPK beta 1+AMPK beta 2 (Ser182/Ser184) Polyclonal Antibody can be used in IHC-P,IHC-Fr,ICC/IF,IF,FCM. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Dog,Cow,Horse,Rabbit) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500; FCM: 2μg/Test |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Tissue Specificity | Highly expressed in kidney, heart, white adipose tissue, lung and spleen. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008]. |
| Immunogen | KLH conjugated synthesised phosphopeptide: human AMPK beta 1 around the phosphorylation site of Ser182 |
| Antigen Species | Human |
| Gene Name | PRKAB1 |
| Gene ID | |
| Protein Name | 5'-AMP-activated protein kinase subunit beta-1 |
| Uniprot ID | |
| Function | Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). |
| Molecular Weight | Theoretical: 30 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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