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Phen-DC3 Trifluoromethanesulfonate
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Catalog No. T13817LCas No. 929895-45-4
Alias Phen-DC3 Triflate
Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand that inhibits FANCJ and DinG helicases with IC50s of 65±6 nM and 50±10 nM, respectively.
Phen-DC3 Trifluoromethanesulfonate
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Catalog No. T13817LAlias Phen-DC3 TriflateCas No. 929895-45-4
Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand that inhibits FANCJ and DinG helicases with IC50s of 65±6 nM and 50±10 nM, respectively.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 mg | Inquiry | Inquiry | Inquiry | |
| 100 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand that inhibits FANCJ and DinG helicases with IC50s of 65±6 nM and 50±10 nM, respectively. |
| Targets&IC50 | FANCJ helicase (G4 substrate):65±6 nM, DinG helicases (G4 substrate):50±10 nM |
| In vitro | The CEB25-L111(T) array remains stable in wild-type (WT) cells but exhibits instability when treated with Phen-DC3 Trifluoromethanesulfonate or upon PIF1 gene deletion. Similarly, the CEB1-WT array, while generally stable, shows frequent rearrangements after exposure to 10 μM Phen-DC3 Trifluoromethanesulfonate in WT cells. The c-Myc allele is significantly destabilized following Phen-DC3 Trifluoromethanesulfonate treatment or PIF1 deletion, revealing high susceptibility to destabilization under these conditions. Meanwhile, the CEB1-loop CEB25 allele maintains full stability in both scenarios involving PIF1 treatment or in WT cells, indicating a distinct response to these genetic interventions. |
| Synonyms | Phen-DC3 Triflate |
| Molecular Weight | 848.75 |
| Formula | C36H26F6N6O8S2 |
| Cas No. | 929895-45-4 |
| Smiles | [O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.C[n+]1cc(NC(=O)c2ccc3ccc4ccc(nc4c3n2)C(=O)Nc2c[n+](C)c3ccccc3c2)cc2ccccc12 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 34 mg/mL (40.06 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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