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MI-1061

Name: MI-1061
Brand: TargetMol
SKU: T12031
Rating: 4.5 (1 reviews)

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Catalog No. T12031Cas No. 1410737-34-6

MI-1061 is a orally bioavailable inhibitor of MDM2 (MDM2-p53 interaction) (IC50=4.4 nM).

MI-1061

😃Good

Catalog No. T12031Cas No. 1410737-34-6

MI-1061 is a orally bioavailable inhibitor of MDM2 (MDM2-p53 interaction) (IC50=4.4 nM).

Pack Size	Price	Availability
25 mg	$3,598	6-8 weeks
50 mg	Inquiry	6-8 weeks
100 mg	Inquiry	6-8 weeks

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	MI-1061 is a orally bioavailable inhibitor of MDM2 (MDM2-p53 interaction) (IC50=4.4 nM).
Targets&IC50	MDM2:(ki)0.16 nM , MDM2:4.4 nM
In vitro	MI-1061 achieves IC50 of 100 and 250 nM in the SJSA-1 and HCT-116 p53+/+ cell lines, respectively[1].
In vivo	MI-1061 was able to achieve tumor regression in oral SJSA-1 xenograft model mice[1].

Chemical Properties

Molecular Weight	582.45
Formula	C₃₀H₂₆Cl₂FN₃O₄
Cas No.	1410737-34-6
Relative Density.	1.51 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 300 mg/mL (515.07 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7169 mL	8.5844 mL	17.1689 mL	85.8443 mL
5 mM	0.3434 mL	1.7169 mL	3.4338 mL	17.1689 mL
10 mM	0.1717 mL	0.8584 mL	1.7169 mL	8.5844 mL
20 mM	0.0858 mL	0.4292 mL	0.8584 mL	4.2922 mL
50 mM	0.0343 mL	0.1717 mL	0.3434 mL	1.7169 mL
100 mM	0.0172 mL	0.0858 mL	0.1717 mL	0.8584 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc