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MI-1061

Name: MI-1061
Brand: TargetMol
SKU: T12031
Rating: 4.5 (1 reviews)

(Synonyms: MI1061, MI 1061) Copy Product Info

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Synonyms: MI1061, MI 1061

Catalog No. T12031 Copy Product Info

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MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor with IC50 = 4.4 nM and Ki = 0.16 nM. MI-1061 activates p53 and induces apoptosis in SJSA-1 xenograft tumor tissue in mice and is utilized in oncology research focused on p53 signaling regulation, MDM2-mediated tumor suppressor suppression, and apoptosis pathway activation in xenograft tumor models.

Cas No. 1410737-34-6

Pack Size	Price	USA Stock	Global Stock
25 mg	$3,598	6-8 weeks	6-8 weeks
50 mg	Inquiry	6-8 weeks	6-8 weeks
100 mg	Inquiry	6-8 weeks	6-8 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor with IC50 = 4.4 nM and Ki = 0.16 nM. MI-1061 activates p53 and induces apoptosis in SJSA-1 xenograft tumor tissue in mice and is utilized in oncology research focused on p53 signaling regulation, MDM2-mediated tumor suppressor suppression, and apoptosis pathway activation in xenograft tumor models.
Targets & IC50	MDM2:4.4 nM, MDM2:0.16 nM (Ki)
In vitro	Methods：The antiproliferative activity of MI-1061 against cell lines with different p53 phenotypes was detected, and the corresponding IC₅₀ values were determined. Results：The IC₅₀ values of MI-1061 against SJSA-1 and HCT-116 p53⁺/⁺ cells were 100 nM and 250 nM, respectively. It showed extremely weak inhibitory effect on HCT-116 p53⁻/⁻ cells, with an IC₅₀ higher than 10000 nM [1].
In vivo	Methods：Mice bearing SJSA-1 xenografts were orally administered with 100 mg/kg MI-1061 daily for 14 consecutive days, and tumor changes were observed. Results：Daily oral administration of 100 mg/kg MI-1061 led to regression of SJSA-1 xenografts in mice [1].
Synonyms	MI1061, MI 1061

Chemical Properties

Molecular Weight	582.45
Formula	C₃₀H₂₆Cl₂FN₃O₄
Cas No.	1410737-34-6
Smiles	O=C1[C@@]2(C3(N[C@@H](C(NC4=CC=C(C(O)=O)C=C4)=O)[C@@H]2C5=C(F)C(Cl)=CC=C5)CCCCC3)C=6C(N1)=CC(Cl)=CC6
Relative Density.	1.51 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 130 mg/mL (223.2 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (8.58 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7169 mL	8.5844 mL	17.1689 mL	85.8443 mL
5 mM	0.3434 mL	1.7169 mL	3.4338 mL	17.1689 mL
10 mM	0.1717 mL	0.8584 mL	1.7169 mL	8.5844 mL
20 mM	0.0858 mL	0.4292 mL	0.8584 mL	4.2922 mL
50 mM	0.0343 mL	0.1717 mL	0.3434 mL	1.7169 mL
100 mM	0.0172 mL	0.0858 mL	0.1717 mL	0.8584 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc