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Anti-ADAM10 Antibody (2F207)
🥰Excellent
Catalog No. TMAH-00026
Alias RAK, Mammalian disintegrin metalloprotease, MADM, Kuzbanian protein homolog, Kuzbanian, Kuz, HsT18717, HsT 18717, Drosophila, CDw156, CD156c antigen, CD156c, CD 156c, ADAM metallopeptidase domain 10, ADAM 10, AD18, AD10, AD 10, A disintegrin and metalloproteinase domain 10, A disintegrin and metalloprotease domain 10
Anti-ADAM10 Antibody (2F207) is an antibody targeting ADAM10. Anti-ADAM10 Antibody (2F207) can be used in ELISA, FC.
Anti-ADAM10 Antibody (2F207)
Anti-ADAM10 Antibody (2F207)
🥰Excellent
Catalog No. TMAH-00026Alias RAK, Mammalian disintegrin metalloprotease, MADM, Kuzbanian protein homolog, Kuzbanian, Kuz, HsT18717, HsT 18717, Drosophila, CDw156, CD156c antigen, CD156c, CD 156c, ADAM metallopeptidase domain 10, ADAM 10, AD18, AD10, AD 10, A disintegrin and metalloproteinase domain 10, A disintegrin and metalloprotease domain 10
Anti-ADAM10 Antibody (2F207) is an antibody targeting ADAM10. Anti-ADAM10 Antibody (2F207) can be used in ELISA, FC.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-ADAM10 Antibody (2F207) is an antibody targeting ADAM10. Anti-ADAM10 Antibody (2F207) can be used in ELISA, FC. |
| Alias | RAK, Mammalian disintegrin metalloprotease, MADM, Kuzbanian protein homolog, Kuzbanian, Kuz, HsT18717, HsT 18717, Drosophila, CDw156, CD156c antigen, CD156c, CD 156c, ADAM metallopeptidase domain 10, ADAM 10, AD18, AD10, AD 10, A disintegrin and metalloproteinase domain 10, A disintegrin and metalloprotease domain 10 |
| Ig Type | Mouse IgG2a |
| Clone | 2F207 |
| Reactivity | Human |
| Verified Activity | Overlay Peak curve showing Hela cells stained with TMAH-00026 (red line) at 1:400. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1µg/1*10^6 cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1µg/1*10^6 cells) used under the same conditions. Acquisition of >10, 000 events was performed. |
| Application | ELISA, FC |
| Recommended Dose | FC:1:20-1:500. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle. Cell projection, axon. Cell projection, dendrite. Cell junction, adherens junction. Cytoplasm. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Research Background | Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and i... |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human ADAM10 protein |
| Antigen Species | Human |
| Gene ID | 102 |
| Uniprot ID | |
| Biology Area | Cancer, Cell biology, Signal transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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