Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ensaculin (Anseculin), a novel benzopyrone partially substituted with piperazine, showed memory-enhancing effects in passive and conditioned avoidance paradigms in normal and artificially amnesic rodents. It showed neuroprotective activity in a model of NMDA toxicity and neurotrophic effects in primary cultured rat brain cells.Ensaculin can be used for the treatment of dementia.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 128.00 | |
5 mg | In stock | $ 320.00 | |
10 mg | In stock | $ 470.00 | |
25 mg | In stock | $ 772.00 | |
50 mg | In stock | $ 1,080.00 | |
100 mg | In stock | $ 1,460.00 | |
500 mg | In stock | $ 2,920.00 |
Description | Ensaculin (Anseculin), a novel benzopyrone partially substituted with piperazine, showed memory-enhancing effects in passive and conditioned avoidance paradigms in normal and artificially amnesic rodents. It showed neuroprotective activity in a model of NMDA toxicity and neurotrophic effects in primary cultured rat brain cells.Ensaculin can be used for the treatment of dementia. |
Targets&IC50 | D2:16.6 nM, D3:27.7 nM, D4:277 nM, α1A:4.7 nM, α1B:9.3 nM, α:>100 nM, 5-HT1A:8 nM, 5-HT2:>100 nM |
In vivo | Ensaculin (0.1, 1 and 10 mg/kg; i.p.; Wistar rats; 20 min after the onset of glutamate perfusion) significantly antagonized the formation of 2,3-DHBA, to values of 60.5% and 56.7% of control levels, respectively. Ensaculin may be useful in the treatment of neurodegenerative disorders associated with elevated hydroxyl free radicals and excitotoxicity.[1] |
Synonyms | Anseculin |
Molecular Weight | 452.54 |
Formula | C26H32N2O5 |
CAS No. | 155773-59-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 42.6 mg/mL (94.03 mM ), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Ensaculin 155773-59-4 Anseculin inhibitor inhibit