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Finasteride

Name: Finasteride
Brand: TargetMol
SKU: T0488
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0488Cas No. 98319-26-7

Alias MK-906

Finasteride (MK-906) is an oral inhibitor of active testosterone 5-alpha-reductase and Ki value is 10 nM.

Finasteride

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Purity: 99.97%

Catalog No. T0488Alias MK-906Cas No. 98319-26-7

Finasteride (MK-906) is an oral inhibitor of active testosterone 5-alpha-reductase and Ki value is 10 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$35	In Stock	In Stock
100 mg	$48	In Stock	In Stock
200 mg	$80	In Stock	In Stock
500 mg	$128	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.97%

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Finasteride (MK-906) is an oral inhibitor of active testosterone 5-alpha-reductase and Ki value is 10 nM.
Targets&IC50	5α reductase:10. nM(Ki)
In vitro	After 4, 9, 14, and 21 days, rat prostates were excised to measure androgen and DNA content and to undergo histological and morphological analyses. On day 21, finasteride levels decreased by 65%. Finasteride treatment induced a dose-dependent increase in the incidence of hypospadias (penischisis) in male offspring, with a threshold dose level of approximately 0.1 mg/kg/day and a 100% effect level at 100 mg/kg/day (administered on gestational day 20). Additionally, finasteride reduced the anogenital distance in male offspring rats. After 4 days of treatment with finasteride, DNA content was almost unaffected, but a decrease of up to 52% was observed at 14 days. After prostate sections were stained, 23% of epithelial cells displayed markers of apoptotic cell death on day 14, returning to control levels by day 21. Finasteride caused 16% of epithelial cells to stain for tissue transglutaminase on day 9, with a return to baseline by day 14. Finasteride-induced staining was less intense at 4 days, peaking at 0.7% of epithelial cells and returning to control values by day 9.
In vivo	Finasteride inhibits the growth rate of prostate lymph node carcinoma cell lines in a dose-dependent manner and significantly suppresses the secretion and expression of prostate-specific antigen in LNCaP cells. It forms a ternary complex with the reduced coenzyme II of type 2 isoenzyme (Ki: 1.19 nM), which then rearranges into a high-affinity complex (E:Ⅰ) with an approximate first-order rate constant of 1.62ms.
Synonyms	MK-906

Chemical Properties

Molecular Weight	372.54
Formula	C₂₃H₃₆N₂O₂
Cas No.	98319-26-7
Smiles	C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@@](CC3)(NC(=O)C=C4)[H])(CC1)[H])[H])(CC[C@@H]2C(NC(C)(C)C)=O)[H]
Relative Density.	1.065 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 37.3 mg/mL (100.12 mM), Sonication is recommended.

DMSO: 64 mg/mL (171.79 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6843 mL	13.4214 mL	26.8428 mL	134.2138 mL
5 mM	0.5369 mL	2.6843 mL	5.3686 mL	26.8428 mL
10 mM	0.2684 mL	1.3421 mL	2.6843 mL	13.4214 mL
20 mM	0.1342 mL	0.6711 mL	1.3421 mL	6.7107 mL
50 mM	0.0537 mL	0.2684 mL	0.5369 mL	2.6843 mL
100 mM	0.0268 mL	0.1342 mL	0.2684 mL	1.3421 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc