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Acalisib

Name: Acalisib
Brand: TargetMol
SKU: T2682
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2682Cas No. 870281-34-8

Alias GS-9820, CAL-120

Acalisib (CAL-120) (GS-9820) is a potent and selective inhibitor of PI3Kδ.

Acalisib

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Purity: 98.99%

Catalog No. T2682Alias GS-9820, CAL-120Cas No. 870281-34-8

Acalisib (CAL-120) (GS-9820) is a potent and selective inhibitor of PI3Kδ.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$33	In Stock	In Stock
10 mg	$55	In Stock	In Stock
25 mg	$98	In Stock	In Stock
50 mg	$148	In Stock	In Stock
100 mg	$208	In Stock	In Stock
200 mg	$312	-	In Stock
1 mL x 10 mM (in DMSO)	$34	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.99%

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Acalisib AI Summary

Acalisib exhibits antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells at 10 µM concentration after 48 hours, with an inhibition rate of -4.74%. It also shows inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM, achieving an inhibition percentage of 22.62%. In terms of enzyme inhibition, compound 2341194 demonstrates bioactivity against Vps34 and GST-tagged PI3Kgamma with IC50 values of 2500.0 nM and 3000.0 nM, respectively. Furthermore, it is a potent inhibitor of the PI3Kdelta enzyme, with an IC50 value of 12.7 nM, and shows cytotoxicity against human basophil cells with an IC50 of 19.0 nM. It also exhibits a high selectivity ratio for PI3Kalpha and PI3Kbeta compared to GST-tagged PI3Kdelta, indicating potential selectivity for these isoforms. Additionally, enzymatic assays indicate that compound 2341194 inhibits human HDAC6 enzyme activity, with an inhibition of 15.2% on the commercial peptide substrate and 4.24% on the custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Acalisib (CAL-120) (GS-9820) is a potent and selective inhibitor of PI3Kδ.
Targets&IC50	p110β:3377 nM, hVps34:12682 nM, p110δ:14 nM, p110α:5441 nM, DNA-PK:18749 nM, p110γ:1389 nM
Synonyms	GS-9820, CAL-120

Chemical Properties

Molecular Weight	401.4
Formula	C₂₁H₁₆FN₇O
Cas No.	870281-34-8
Smiles	C[C@H](Nc1ncnc2[nH]cnc12)c1nc2ccc(F)cc2c(=O)n1-c1ccccc1
Relative Density.	1.50 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 73 mg/mL (181.86 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.98 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4913 mL	12.4564 mL	24.9128 mL	124.5640 mL
5 mM	0.4983 mL	2.4913 mL	4.9826 mL	24.9128 mL
10 mM	0.2491 mL	1.2456 mL	2.4913 mL	12.4564 mL
20 mM	0.1246 mL	0.6228 mL	1.2456 mL	6.2282 mL
50 mM	0.0498 mL	0.2491 mL	0.4983 mL	2.4913 mL
100 mM	0.0249 mL	0.1246 mL	0.2491 mL	1.2456 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc