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rTRD01
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Catalog No. T81251Cas No. 1332175-56-0
Alias rTRD-01, rTRD 01
rTRD01 is a small-molecule TDP-43 ligand that binds the RRM1 and RRM2 domains of TDP-43 and partially disrupts its interaction with the pathogenic hexanucleotide RNA repeat of the c9orf72 gene, supporting the application of rTRD01 in mechanistic studies of RNA binding dysregulation in neurodegenerative disease research.
rTRD01
😃Good
Purity: 99.44%
Catalog No. T81251Alias rTRD-01, rTRD 01Cas No. 1332175-56-0
rTRD01 is a small-molecule TDP-43 ligand that binds the RRM1 and RRM2 domains of TDP-43 and partially disrupts its interaction with the pathogenic hexanucleotide RNA repeat of the c9orf72 gene, supporting the application of rTRD01 in mechanistic studies of RNA binding dysregulation in neurodegenerative disease research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $68 | - | In Stock | |
| 5 mg | $163 | - | In Stock | |
| 10 mg | $263 | - | In Stock | |
| 25 mg | $529 | - | In Stock | |
| 50 mg | $848 | - | In Stock | |
| 100 mg | $1,130 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.44%
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | rTRD01 is a small-molecule TDP-43 ligand that binds the RRM1 and RRM2 domains of TDP-43 and partially disrupts its interaction with the pathogenic hexanucleotide RNA repeat of the c9orf72 gene, supporting the application of rTRD01 in mechanistic studies of RNA binding dysregulation in neurodegenerative disease research. |
| In vitro | In biophysical assays using Microscale Thermophoresis, rTRD01 bound to the TDP-43 RRM1-RRM2 construct with a Kd of 89 μM. This interaction modulated TDP-43 binding to specific RNA sequences (UG-rich repeats), preventing aberrant protein-RNA interactions associated with aggregation [1]. |
| In vivo | In flies expressing human TDP-43, which typically display locomotor defects, treatment with rTRD01 led to a reduction in motor dysfunctions [1]. |
| Synonyms | rTRD-01, rTRD 01 |
| Molecular Weight | 344.38 |
| Formula | C18H21FN4O2 |
| Cas No. | 1332175-56-0 |
| Smiles | O=C(N)C=1N=C(C=NC1)N2CCCC(CO)(CC3=CC=C(F)C=C3)C2 |
| Color | Yellow |
| Appearance | Solid |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (232.3 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
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