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Dim16 HCl
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Catalog No. T78718LCas No. 2743448-41-9
Alias Dim16 HCl（2743448-32-8 Free base）, Dim16 HCl
Dim16 HCl is a dual inhibitor of PCSK9 and HMG-CoA reductase that exhibits an IC50 value of 19 nM for PCSK9, potently blocks PCSK9–LDLR binding with an IC50 of 0.8 nM, and increases LDL uptake in HepG2 cells, supporting its use in lipid metabolism and cardiovascular research.
Dim16 HCl
😃Good
Purity: 99.07%
Catalog No. T78718LAlias Dim16 HCl（2743448-32-8 Free base）, Dim16 HClCas No. 2743448-41-9
Dim16 HCl is a dual inhibitor of PCSK9 and HMG-CoA reductase that exhibits an IC50 value of 19 nM for PCSK9, potently blocks PCSK9–LDLR binding with an IC50 of 0.8 nM, and increases LDL uptake in HepG2 cells, supporting its use in lipid metabolism and cardiovascular research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $588 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.07%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Dim16 HCl is a dual inhibitor of PCSK9 and HMG-CoA reductase that exhibits an IC50 value of 19 nM for PCSK9, potently blocks PCSK9–LDLR binding with an IC50 of 0.8 nM, and increases LDL uptake in HepG2 cells, supporting its use in lipid metabolism and cardiovascular research. |
| Targets&IC50 | PCSK9-LDLR binding:0.8 nM, PCSK9:19 nM |
| In vitro | Method: Small-molecule inhibitors of the PCSK9–LDLR interaction were designed and evaluated using biochemical and cellular assays. Result: Compound Dim16 HCl potently inhibited PCSK9 with an IC50 of 0.9 nM and showed cholesterol-lowering activity, with some analogues also inhibiting HMG-CoA reductase[1]. |
| Synonyms | Dim16 HCl（2743448-32-8 Free base）, Dim16 HCl |
| Molecular Weight | 620.01 |
| Formula | C29H39ClIN5 |
| Cas No. | 2743448-41-9 |
| Smiles | Cl.IC1=NC=C(C2=NC=C(C=3C=CC=4C=CC=CC4C3)N2CCCC(C)(C)C)N1CCCCCNC |
| Relative Density. | no data available |
| Color | Yellow |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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