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Norverapamil hydrochloride

Name: Norverapamil hydrochloride
Brand: TargetMol
SKU: T16339
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16339Cas No. 67812-42-4

Alias D591 hydrochloride, (±)-Norverapamil hydrochloride

Norverapamil hydrochloride (D591 hydrochloride) ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.

Norverapamil hydrochloride

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Purity: 99.47%

Catalog No. T16339Alias D591 hydrochloride, (±)-Norverapamil hydrochlorideCas No. 67812-42-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
5 mg	$113	In Stock	In Stock
10 mg	$197	In Stock	In Stock
25 mg	$332	In Stock	In Stock
50 mg	$496	In Stock	In Stock
100 mg	$668	In Stock	In Stock
200 mg	$935	-	In Stock
1 mL x 10 mM (in DMSO)	$118	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.47%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Norverapamil hydrochloride (D591 hydrochloride) ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.
In vitro	Norverapamil inhibits macrophage-induced tolerance and attains serum levels comparable to verapamil. Both verapamil and its primary metabolite, Norverapamil, are identified as mechanism-based inhibitors and substrates of CYP3A, exhibiting non-linear pharmacokinetics clinically. Furthermore, ((±)-Norverapamil hydrochloride) proves as effective as verapamil in inhibiting tolerance and killing intracellular M. tuberculosis in monotherapy, matching its efficacy against isoniazid and rifampicin tolerance [1][3].
In vivo	Norverapamil hydrochloride (9 mg/kg; p.o.) exhibits a terminal half-life of 9.4 hours, an AUC of 260 ng ml−1 h, and a Cmax of 41.6 ng/mL[4].
Synonyms	D591 hydrochloride, (±)-Norverapamil hydrochloride

Chemical Properties

Molecular Weight	477.04
Formula	C₂₆H₃₇ClN₂O₄
Cas No.	67812-42-4
Smiles	Cl.COc1ccc(CCNCCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (104.81 mM), Sonication is recommended.

DMSO: 31 mg/mL (64.98 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.19 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.0963 mL	10.4813 mL	20.9626 mL	104.8130 mL
5 mM	0.4193 mL	2.0963 mL	4.1925 mL	20.9626 mL
10 mM	0.2096 mL	1.0481 mL	2.0963 mL	10.4813 mL
20 mM	0.1048 mL	0.5241 mL	1.0481 mL	5.2407 mL
50 mM	0.0419 mL	0.2096 mL	0.4193 mL	2.0963 mL

H2O

	1mg	5mg	10mg	50mg
100 mM	0.0210 mL	0.1048 mL	0.2096 mL	1.0481 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc