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Forodesine hydrochloride

Name: Forodesine hydrochloride
Brand: TargetMol
SKU: T11313
Rating: 4.5 (1 reviews)

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Catalog No. T11313Cas No. 284490-13-7

Alias Immucillin-H hydrochloride, BCX-1777 hydrochloride

Forodesine hydrochloride (BCX-1777 hydrochloride), a potent inhibitor of human lymphocyte proliferation, effectively induces apoptosis in leukemic cells by elevating dGTP levels. This compound is an orally active, highly potent purine nucleoside phosphorylase (PNP) inhibitor, demonstrating IC50 values between 0.48 to 1.57 nM across human, mouse, rat, monkey, and dog PNP.

Forodesine hydrochloride

😃Good

Catalog No. T11313Alias Immucillin-H hydrochloride, BCX-1777 hydrochlorideCas No. 284490-13-7

Pack Size	Price	Availability
25 mg	Inquiry	3-6 months
50 mg	Inquiry	3-6 months
100 mg	Inquiry	3-6 months

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Forodesine hydrochloride (BCX-1777 hydrochloride), a potent inhibitor of human lymphocyte proliferation, effectively induces apoptosis in leukemic cells by elevating dGTP levels. This compound is an orally active, highly potent purine nucleoside phosphorylase (PNP) inhibitor, demonstrating IC50 values between 0.48 to 1.57 nM across human, mouse, rat, monkey, and dog PNP.
Targets&IC50	PNP (mouse):0.48 nM , PNP (monkey):0.66 nM , PNP (rat):1.24 nM , PNP (human):1.19 nM , PNP (dog):1.57 nM
In vitro	Forodesine (BCX-1777), in the presence of 2'-deoxyguanosine (dGuo, 3-10 μM), inhibits human lymphocyte proliferation activated by various agents such as interleukin-2 (IL-2), mixed lymphocyte reaction (MLR) and phytohemagglutinin (PHA) (IC50 values
In vivo	In the hu-PBL-SCID mouse model, Forodesine (BCX-1777) demonstrates efficacy in extending lifespan by two-fold or greater. This compound exhibits outstanding oral bioavailability (63%) in mice. When administered at a single dose of 10 mg/kg, it significantly increases dGuo levels to around 5 μM.
Synonyms	Immucillin-H hydrochloride, BCX-1777 hydrochloride

Chemical Properties

Molecular Weight	302.71
Formula	C₁₁H₁₅ClN₄O₄
Cas No.	284490-13-7
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16.67 mg/mL (55.07 mM), Sonication is recommended.

H2O: 16.67 mg/mL (55.07 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.3035 mL	16.5175 mL	33.0349 mL	165.1746 mL
5 mM	0.6607 mL	3.3035 mL	6.6070 mL	33.0349 mL
10 mM	0.3303 mL	1.6517 mL	3.3035 mL	16.5175 mL
20 mM	0.1652 mL	0.8259 mL	1.6517 mL	8.2587 mL
50 mM	0.0661 mL	0.3303 mL	0.6607 mL	3.3035 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc