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Rac1-IN-5
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Catalog No. T212219Cas No. 694515-65-6
Rac1-IN-5 is a selective, reversible inhibitor of the RAC1 protein with a dissociation constant (KD) of 30 nM. It competes specifically with guanine nucleotides for binding to RAC proteins, effectively blocking RAC1 activity and RAC1-dependent cellular functions. In vivo, Rac1-IN-5 exhibits anti-tumor metastasis effects and can improve survival rates. This compound is applicable for research on aggressive cancers such as triple-negative breast cancer and colon cancer.
Rac1-IN-5
Copy Product Info😃Good
Catalog No. T212219Cas No. 694515-65-6
Rac1-IN-5 is a selective, reversible inhibitor of the RAC1 protein with a dissociation constant (KD) of 30 nM. It competes specifically with guanine nucleotides for binding to RAC proteins, effectively blocking RAC1 activity and RAC1-dependent cellular functions. In vivo, Rac1-IN-5 exhibits anti-tumor metastasis effects and can improve survival rates. This compound is applicable for research on aggressive cancers such as triple-negative breast cancer and colon cancer.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Rac1-IN-5 is a selective, reversible inhibitor of the RAC1 protein with a dissociation constant (KD) of 30 nM. It competes specifically with guanine nucleotides for binding to RAC proteins, effectively blocking RAC1 activity and RAC1-dependent cellular functions. In vivo, Rac1-IN-5 exhibits anti-tumor metastasis effects and can improve survival rates. This compound is applicable for research on aggressive cancers such as triple-negative breast cancer and colon cancer. |
| In vitro | Rac1-IN-5 (Compound A41) at 10 μM for 1 hour inhibits RAC1 activation and its dependent functions in EGF-stimulated NIH/3T3 fibroblasts. Additionally, Rac1-IN-5 at 10 μM decreases the activity of RAC P29S and RAC1b in NIH-3T3 fibroblasts expressing RAC wild-type (RAC1 WT) or RAC1 mutants (RAC1 P29S and RAC1b). In the concentration range of 0.01-10 μM, Rac1-IN-5 reduces RAC1-GTP levels, suppresses AKT hyperactivation, limits sphere migration areas, and inhibits colony formation in TNBC MDA-MB-468 luciferase (Luc) cells (IC 50 = 2.1 μM). Rac1-IN-5 also exhibits anti-invasive properties in human breast CAF spheroids at 10 μM. |
| In vivo | Rac1-IN-5 (Compound A41) administered at 25 mg/kg via intraperitoneal injection once daily for 4 weeks can prevent cancer cell metastasis in a mouse TNBC model. Additionally, Rac1-IN-5 at the same dosage and method of administration over 15 days can inhibit the metastasis of aggressive cancer in a CT26 cell xenograft BALB/c female mouse model. |
| Molecular Weight | 486.60 |
| Formula | C24H26N2O5S2 |
| Cas No. | 694515-65-6 |
| Smiles | O=C(NC1=CC=C(C=C1)S(=O)(=O)NC2=CC(OC)=CC=C2OC)CCSC3=CC=C(C=C3)C |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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