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Protease-activated Receptor

Protease-activated receptors (PAR) are a subfamily of related G protein-coupled receptors that are activated by cleavage of part of their extracellular domain. They are highly expressed in platelets, and also on endothelial cells, myocytes and neurons.

FilterSignaling PathwaysGPCR/G ProteinProtease-activated Receptor
  • TFLLR-NH2 2TFA(197794-83-5(free base))
    T7573L
    TFLLR-NH2 2TFA(197794-83-5(free base)) is an agonist of PAR1 (EC50 :1.9 μM).
    • $133
    In Stock
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    QTY
  • 2-Furoyl-LIGRLO-amide TFA(729589-58-6 free base)
    TP1378
    2-Furoyl-LIGRLO-amide TFA(729589-58-6 free base) is a potent and selective protease-activated receptor 2 (PAR2) agonist.
    • $50
    In Stock
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    QTY
  • PAR-2 Activating Peptide acetate
    TP1046L
    PAR-2 Activating Peptide acetate (SLIGRL-NH2 acetate) is an agonist of Protease-Activated Receptor-2 (PAR-2).
    • $78
    In Stock
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    QTY
  • Protease-Activated Receptor-4 diTFA
    T7740
    Protease-Activated Receptor-4 diTFA,2454 is the proteinase-activated receptor-4 (PAR4)agonist
    • $40
    In Stock
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    QTY
  • Thrombin Receptor Activator for Peptide
    T7674
    Thrombin Receptor Activator for Peptide is also called Coagulation Factor II Receptor (1-5) or Proteinase Activated Receptor 1 (1-5), used in the research of coronary heart disease (CHD).
    • $65
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • BMS-986141
    T639661478711-48-6In house
    BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an IC50 value of 0.4 nM.BMS-98614 exhibits significant antithrombotic effects.
    • $963
    In Stock
    Size
    QTY
  • tcY-NH2 TFA(327177-34-4 free base)
    TP1925L
    tcY-NH2 TFA is a selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.
    • $177
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • LRGILS-NH2 acetate
    T22933L
    LRGILS-NH2 acetate is a PAR-2-inactive reversed peptide.
    • $59
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • TRAP-6 amide acetate
    T38852L
    TRAP-6 amide acetate is a PAR-1 thrombin receptor agonist peptide[1].
    • $148
    In Stock
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    QTY
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  • AY 77
    T411901835734-92-3In house
    AY 77 (Unk-Cha-Chg-NH2) is a potent and selective PAR2 agonist. AY 77 showed selectivity for Ca2+ and ERK1/2 signaling (ec50 value of Ca2+ release was 40 nM and ec50 value of ERK1/2 phosphorylation was 2 μM). AY 77 can promote migration of human breast cancer cells in vitro.
    • $686
    In Stock
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    QTY
  • ENMD-1068 HCl
    T27267789488-77-3
    ENMD-1068 HCl (ENMD 1068) is a PAR-2 antagonist. ENMD-1068 HCl inhibits the development of endometriosis in a mouse model.
    • $50
    In Stock
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    QTY
  • VKGILS-NH2 Acetate
    T21699L
    VKGILS-NH2 Acetate is a reversed amino acid sequence control peptide for SLIGKV-NH2, a protease-activated receptor 2 (PAR2) agonist.
    • $52
    In Stock
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    QTY
    TargetMol | Inhibitor Sale
  • Protease-Activated Receptor-1, PAR-1 Agonist acetate
    T38836L
    Protease-Activated Receptor-1, PAR-1 Agonist acetate is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist acetate corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor[1][2].
    • $133
    In Stock
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  • FSLLRY-NH2 TFA(245329-02-6 free base)
    TP1904L
    FSLLRY-NH2 TFA is a is a protease-activated receptor 2 (PAR2) inhibitor. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch.
    • $98
    In Stock
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  • Atopaxar
    T1986751475-53-3In house
    Atopaxar (E5555), a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling. Atopaxar has been investigated for the treatment of Coronary Artery Disease and Acute Coronary Syndrome.
    • $67
    In Stock
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  • Vorapaxar
    T7013618385-01-6
    Vorapaxar (MK-5348) (SCH 530348) is an effective and orally active thrombin receptor (PAR-1) antagonist (Ki: 8.1 nM).
    • $68
    In Stock
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    TargetMol | Citations Cited
  • Parmodulin 2
    T1893423735-93-7
    Parmodulin 2 (ML 161) is the inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50: 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). It also inhibits thrombin-induced platelet activation.
    • $30
    In Stock
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    TargetMol | Citations Cited
  • Atopaxar Hydrobromide
    T1986L474550-69-1
    Atopaxar, a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling. Atopaxar has been investigated for the treatment of Coronary Artery Disease and Acute Coronary Syndrome.
    • $257
    In Stock
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    QTY
    TargetMol | Inhibitor Sale
    TargetMol | Citations Cited
  • TFLLR-NH2
    T7573197794-83-5
    TFLLR-NH2(2TFA) is an agonist of PAR1 (EC50 :1.9 μM).
    • $970
    35 days
    Size
    QTY
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  • Thrombin Receptor Activator for Peptide 5 (TRAP-5)
    T7496141685-53-2
    Thrombin Receptor Activator for Peptide 5 (TRAP-5), also known as Coagulation Factor II Receptor (1-5) or Proteinase Activated Receptor 1 (1-5), is employed in coronary heart disease (CHD) research.
    • $71
    Backorder
    Size
    QTY
    TargetMol | Inhibitor Sale
  • AC-264613
    T41861051487-82-1
    AC-264613 is an agonist of the GPCR protease-activated receptor 2 (PAR2). AC-264613(AC264613) suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macrophages. AC-264613(AC264613) activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 30 to 100 nM.
    • $93
    35 days
    Size
    QTY
    TargetMol | Inhibitor Sale
  • AC-55541
    T2370916170-19-9
    AC-55541 (AOB2796) is a novel PAR2 agonist; activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 200 to 1000 nM.
    • $36
    In Stock
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  • Protease-Activated Receptor-4
    T7380245443-52-1
    Protease-Activated Receptor-4 is the proteinase-activated receptor-4 (PAR4) agonist, with Antiplatelet Therapy
      7-10 days
      Inquiry
    • TRAP-6
      T7625141136-83-6
      TRAP-6 (Thrombin Receptor Activator Peptide 6)(2TFA) is an agonist of protease-activated receptor 1 (PAR1).
      • $34
      In Stock
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    • PAR-2-IN-1
      T89171690176-75-0
      PAR-2-IN-1 (IUN76750) is a PAR- 2 signaling pathway inhibitor with anti-inflammatory and anticancer effects.
      • $34
      In Stock
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    • SCH79797 dihydrochloride
      T128701216720-69-2
      SCH79797 dihydrochloride is an effective and selective antagonist of protease activated receptor 1 (PAR1) with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects.
      • $54
      In Stock
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    • I-191
      T71371690172-25-8
      I-191 is a potent antagonist of protease-activated receptor 2 (PAR2), inhibits multiple signaling functions in human cancer cells.
      • $82
      In Stock
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    • Protease-Activated Receptor-2, amide
      T7513190383-13-2
      Protease-Activated Receptor-2, amide (SLIGKV-NH2) is an agonist of PAR2 (IC50 : 10.4 M)
      • $48
      In Stock
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    • SLIGRL-NH2
      TP1046171436-38-7
      SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) is a protease-activated receptor-2 (PAR-2) agonist that induces non-histaminergic pruritus.
      • $99
      In Stock
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    • PAR-4 Agonist Peptide, amide acetate
      T7623L
      PAR-4 Agonist Peptide, amide acetate is an agonist of proteinase-activated receptor-4 (PAR-4).
      • $98
      Backorder
      Size
      QTY
    • PAR-4 Agonist Peptide, amide TFA
      TP10651228078-65-6
      PAR-4 Agonist Peptide, amide TFA (PAR-4-AP (TFA)), is a selective activator of the proteinase-activated receptor-4 (PAR-4), demonstrating specificity by not influencing PAR-1 or PAR-2, and its activity can be inhibited by a PAR-4 antagonist.
      • $47
      In Stock
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    • Vorapaxar sulfate
      T3098705260-08-8
      Vorapaxar sulfate (Zontivity) is a potent and orally active thrombin receptor (PAR-1) antagonist.
      • $32
      In Stock
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      QTY
    • AZ3451
      TQ00122100284-59-9
      AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM).
      • $38
      In Stock
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    • PAR-4 Agonist Peptide, amide
      T7623352017-71-1
      PAR-4 Agonist Peptide, amide (AY-NH2) is an agonist of proteinase-activated receptor-4 (PAR-4).
      • $47
      In Stock
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      QTY
      TargetMol | Inhibitor Sale
    • Trypsin
      TN68729002-07-7
      Trypsin is a serine protease that can be isolated from fish to hydrolyze lysine or arginine carboxy-side proteins. With the anti-inflammatory activity, Trypsin could induce the cell membrane fusion of PDCoV-infected cells through the interaction between the S glycoprotein of PDCoV and pAPN, activate PAR2 and PAR4, and promote cell proliferation and differentiation. Trypsin can be used to promote wound healing and study neurogenic inflammation.
      • $39
      In Stock
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