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Anti-CD83 Antibody is a humanized monoclonal antibody targeting CD83, a marker for mature dendritic cells (DCs). It interferes with immunomodulatory functions by specifically binding to the extracellular domain of CD83. The antibody works by depleting CD83+ cells or blocking costimulatory signals, serving as an advanced compound tool for studying immune tolerance induction, graft-versus-host disease (GvHD) suppression, and autoimmune disease treatment.

| Description | Anti-CD83 Antibody is a humanized monoclonal antibody targeting CD83, a marker for mature dendritic cells (DCs). It interferes with immunomodulatory functions by specifically binding to the extracellular domain of CD83. The antibody works by depleting CD83+ cells or blocking costimulatory signals, serving as an advanced compound tool for studying immune tolerance induction, graft-versus-host disease (GvHD) suppression, and autoimmune disease treatment. |
| In vitro | In primary human and mouse dendritic cell cultures, Anti-CD83 Antibody (3E12) targeted mature DCs and inhibited their capacity to stimulate T cell responses [1]. |
| In vivo | In a mouse model of collagen-induced arthritis, systemic administration of Anti-CD83 Antibody (3E12) provided significant protection against joint inflammation and bone destruction [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | CD83 |
| Isotype | IgG2SA |
| Storage | store at low temperature | -20°C for 2 years, 4°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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