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Anti-CD83 Antibody

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Catalog No. T9901A-1308

Anti-CD83 Antibody is a humanized monoclonal antibody targeting CD83, a marker for mature dendritic cells (DCs). It interferes with immunomodulatory functions by specifically binding to the extracellular domain of CD83. The antibody works by depleting CD83+ cells or blocking costimulatory signals, serving as an advanced compound tool for studying immune tolerance induction, graft-versus-host disease (GvHD) suppression, and autoimmune disease treatment.

Anti-CD83 Antibody

Anti-CD83 Antibody

Copy Product Info
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Catalog No. T9901A-1308
Anti-CD83 Antibody is a humanized monoclonal antibody targeting CD83, a marker for mature dendritic cells (DCs). It interferes with immunomodulatory functions by specifically binding to the extracellular domain of CD83. The antibody works by depleting CD83+ cells or blocking costimulatory signals, serving as an advanced compound tool for studying immune tolerance induction, graft-versus-host disease (GvHD) suppression, and autoimmune disease treatment.
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Product Introduction

Bioactivity
Description
Anti-CD83 Antibody is a humanized monoclonal antibody targeting CD83, a marker for mature dendritic cells (DCs). It interferes with immunomodulatory functions by specifically binding to the extracellular domain of CD83. The antibody works by depleting CD83+ cells or blocking costimulatory signals, serving as an advanced compound tool for studying immune tolerance induction, graft-versus-host disease (GvHD) suppression, and autoimmune disease treatment.
In vitro
In primary human and mouse dendritic cell cultures, Anti-CD83 Antibody (3E12) targeted mature DCs and inhibited their capacity to stimulate T cell responses [1].
In vivo
In a mouse model of collagen-induced arthritis, systemic administration of Anti-CD83 Antibody (3E12) provided significant protection against joint inflammation and bone destruction [1].
Reactivity
Human
Application
FACS
Functional assay
Antibody Type
Monoclonal
FormulationSupplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
Endotoxin<1.0 EU/mg
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Uniprot ID
TargetCD83
Chemical Properties
Antibody Information
IsotypeIgG2SA
Storage & Solubility Information
Storagestore at low temperature | -20°C for 2 years, 4°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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