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Beta-Sitosterol
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Catalog No. T2966Cas No. 83-46-5
Alias β-Sitosterol, SKF 14463, Cupreol, Beta-Sitosterol, Betaprost, Azuprostat, 22,23-Dihydrostigmasterol
Beta-Sitosterol (SKF 14463) has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. Beta-Sitosterol (SKF 14463) , a main dietary phytosterol found in plants, may have the potential for prevention and therapy for human cancer. Although the exact mechanism of action of Beta-Sitosterol (SKF 14463) is unknown, it may be related to cholesterol metabolism or anti-inflammatory effects (via interference with prostaglandin metabolism). Beta-Sitosterol (SKF 14463) induces apoptosis and activates key caspases in MDA-MB-231 human breast cancer cells.
Beta-Sitosterol
Copy Product Info🥰Excellent
Purity: 99.95%
Catalog No. T2966Alias β-Sitosterol, SKF 14463, Cupreol, Beta-Sitosterol, Betaprost, Azuprostat, 22,23-DihydrostigmasterolCas No. 83-46-5
Beta-Sitosterol (SKF 14463) has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. Beta-Sitosterol (SKF 14463) , a main dietary phytosterol found in plants, may have the potential for prevention and therapy for human cancer. Although the exact mechanism of action of Beta-Sitosterol (SKF 14463) is unknown, it may be related to cholesterol metabolism or anti-inflammatory effects (via interference with prostaglandin metabolism). Beta-Sitosterol (SKF 14463) induces apoptosis and activates key caspases in MDA-MB-231 human breast cancer cells.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $32 | In Stock | In Stock | |
| 10 mg | $52 | In Stock | In Stock | |
| 25 mg | $106 | In Stock | In Stock | |
| 50 mg | $163 | In Stock | In Stock | |
| 100 mg | $257 | In Stock | In Stock | |
| 500 mg | $369 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.95%
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Beta-Sitosterol (SKF 14463) has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. Beta-Sitosterol (SKF 14463) , a main dietary phytosterol found in plants, may have the potential for prevention and therapy for human cancer. Although the exact mechanism of action of Beta-Sitosterol (SKF 14463) is unknown, it may be related to cholesterol metabolism or anti-inflammatory effects (via interference with prostaglandin metabolism). Beta-Sitosterol (SKF 14463) induces apoptosis and activates key caspases in MDA-MB-231 human breast cancer cells. |
| Targets&IC50 | MCF-7 cells (48 h):36 ± 5.1 µM, MCF-7 cells (24 h):59 ± 3.2 µM, KB cells (24 h):32.58 µM, PPL:99.99 ± 1.86 μg/mL, KB cells (48 h):13.82 µM, HCT116 cells:140 μmol/mL |
| In vitro | Bioactivity-guided isolation from the hexane fraction of E. indica yielded Beta-Sitosterol (β-sitosterol), Stigmasterol, and Lutein. Beta-Sitosterol and Stigmasterol displayed minimal PPL inhibition, with 2.99±0.80% and 2.68±0.38% at 100 μg/mL (242-243 μM) respectively, compared to higher inhibition by Curcumin (IC50=4.92±0.21 μg/mL) and Quercetin (IC50=18.60±0.86 μg/mL). These compounds showed weaker inhibition than literature values (50% PPL inhibition at 100 μg/mL). Beta-Sitosterol, also extracted from Aloe vera, inhibits the growth of L. donovani promastigotes, implicated in visceral leishmaniasis. |
| In vivo | Beta-sitosterol (β-sitosterol) treatment significantly reduced immobility times in mice across all doses tested (10, 20, and 30 mg/kg) in both the Forced Swim Test (FST) and Tail Suspension Test (TST), indicating a notable antidepressant effect. At 30 mg/kg, β-sitosterol's efficacy was comparable to fluoxetine (20 mg/kg) with the most robust effect against the control group (P < 0.001). The percentage decreases in immobility (DID) for FST were 39.27%, 51.23%, and 57.48% for 10, 20, and 30 mg/kg respectively, and for TST were 31.63%, 43.95%, and 53.38% for the same doses, confirming the dose-dependent antidepressant activity of Beta-sitosterol in animal models. |
| Synonyms | β-Sitosterol, SKF 14463, Cupreol, Beta-Sitosterol, Betaprost, Azuprostat, 22,23-Dihydrostigmasterol |
| Molecular Weight | 414.71 |
| Formula | C29H50O |
| Cas No. | 83-46-5 |
| Smiles | C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(=CC3)C[C@@H](O)CC4)(CC1)[H])[H])(CC[C@@]2([C@@H](CC[C@H](C(C)C)CC)C)[H])[H] |
| Relative Density. | 0.9540 g/cm3 (Estimated) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | Ethanol: 3.32 mg/mL (8.01 mM), Sonication is recommended. DMSO: Insoluble | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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