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Belvarafenib

Name: Belvarafenib
Brand: TargetMol
SKU: T5634
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5634Cas No. 1446113-23-0

Belvarafenib (HM95573) is a potent pan-RAF inhibitor with antitumor activity and inhibits B-RAF, B-RAFv600E, and C-RAF with IC50 values of 56, 7, and 5 nM.

Belvarafenib

🥰Excellent

Purity: 99.65%

Catalog No. T5634Cas No. 1446113-23-0

Belvarafenib (HM95573) is a potent pan-RAF inhibitor with antitumor activity and inhibits B-RAF, B-RAFv600E, and C-RAF with IC50 values of 56, 7, and 5 nM.

Pack Size	Price	Availability
1 mg	$42	In Stock
5 mg	$98	In Stock
10 mg	$172	In Stock
25 mg	$347	In Stock
50 mg	$519	In Stock
100 mg	$787	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock

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Purity:99.65%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Belvarafenib (HM95573) is a potent pan-RAF inhibitor with antitumor activity and inhibits B-RAF, B-RAFv600E, and C-RAF with IC50 values of 56, 7, and 5 nM.
Targets&IC50	B-Raf (V600E):7 nM, B-Raf:56 nM, C-Raf:5 nM
In vitro	Belvarafenib (HM95573) inhibited B-RAF, B-RAFv600E and C-RAF with IC50 values of 56, 7 and 5 nM, respectively.[1]
In vivo	METHODS: Data were collected from 192 patients with melanoma who underwent NGS between November 2017 and May 2023.EAP patients were treated with 450 mg of Belvarafenib (HM95573) twice daily. RESULTS Six patients with NRAS or RAF alterations were treated with Belvarafenib (HM95573), and 50% of the patients had control of their disease, including two patients with significant outcomes. [2]

Chemical Properties

Molecular Weight	478.93
Formula	C₂₃H₁₆ClFN₆OS
Cas No.	1446113-23-0
Smiles	Cc1ccc2c(Nc3cccc(Cl)c3F)nccc2c1NC(=O)c1csc2c(N)ncnc12
Relative Density.	1.562 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (52.2 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0880 mL	10.4399 mL	20.8799 mL	104.3994 mL
5 mM	0.4176 mL	2.0880 mL	4.1760 mL	20.8799 mL
10 mM	0.2088 mL	1.0440 mL	2.0880 mL	10.4399 mL
20 mM	0.1044 mL	0.5220 mL	1.0440 mL	5.2200 mL
50 mM	0.0418 mL	0.2088 mL	0.4176 mL	2.0880 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

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