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Motixafortide

Name: Motixafortide
Brand: TargetMol
SKU: T14665
Rating: 4.5 (1 reviews)

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Catalog No. T14665Cas No. 664334-36-5

Alias TF14016, BL-8040, BKT140 (4-fluorobenzoyl)

Motixafortide (BKT140 4-fluorobenzoyl) is a CXCR4 antagonist with an IC50 of 1 nM.

Motixafortide

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Catalog No. T14665Alias TF14016, BL-8040, BKT140 (4-fluorobenzoyl)Cas No. 664334-36-5

Motixafortide (BKT140 4-fluorobenzoyl) is a CXCR4 antagonist with an IC50 of 1 nM.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$747	7-10 days	7-10 days
50 mg	$1,190	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Motixafortide (BKT140 4-fluorobenzoyl) is a CXCR4 antagonist with an IC50 of 1 nM.
Targets&IC50	CXCR4:1 nM
In vitro	Motixafortide (BKT140) exhibits selective toxicity against AmL and MM cells by specifically inducing CXCR4-dependent and apoptotic cell death in these leukemia and multiple myeloma (MM) cell types. Additionally, treatment with Motixafortide (BKT140) counteracts the IL-6 dependent proliferation and survival observed in ARH77 MM cells.
In vivo	Treatment with Motixafortide (BKT140) results in reduced size and weight of tumors in animals, alongside increased necrotic areas and elevated apoptotic scores[2]. Additionally, subcutaneous administration of Motixafortide (BKT140) markedly diminishes the growth of human acute myeloid leukemia and multiple myeloma xenografts in a dose-dependent fashion.
Synonyms	TF14016, BL-8040, BKT140 (4-fluorobenzoyl)

Chemical Properties

Molecular Weight	2159.52
Formula	C₉₇H₁₄₄FN₃₃O₁₉S₂
Cas No.	664334-36-5
Smiles	NCCCC[C@@H]1NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)c1ccc(F)cc1
Relative Density.	1.52 g/cm3 (Predicted)
Sequence	{4-Fluorobenzoyl}-Arg-Arg-{2-Naph-Ala}-Cys-Tyr-{Cit}-Lys-{d-Lys}-Pro-Tyr-Arg-{Cit}-Cys-Arg-NH2 (Disulfide bridge: Cys4-Cys13)
Sequence Short	{4-Fluorobenzoyl}-RR-{2-Naph-Ala}-CY-{Cit}-K-{d-Lys}-PYR-{Cit}-CR (Disulfide bridge: Cys4-Cys13)

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 36 mg/mL (16.67 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.4631 mL	2.3153 mL	4.6307 mL	23.1533 mL
5 mM	0.0926 mL	0.4631 mL	0.9261 mL	4.6307 mL
10 mM	0.0463 mL	0.2315 mL	0.4631 mL	2.3153 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc