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Anti-Streptolysin O Polyclonal Antibody

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Catalog No. TMAB-13246

Anti-Streptolysin O Polyclonal Antibody is a Rabbit antibody targeting Streptolysin O. Anti-Streptolysin O Polyclonal Antibody can be used in WB.

Anti-Streptolysin O Polyclonal Antibody

Anti-Streptolysin O Polyclonal Antibody

😃Good
Catalog No. TMAB-13246
Anti-Streptolysin O Polyclonal Antibody is a Rabbit antibody targeting Streptolysin O. Anti-Streptolysin O Polyclonal Antibody can be used in WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2207-10 days7-10 days
100 μL$3727-10 days7-10 days
200 μL$5277-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-Streptolysin O Polyclonal Antibody is a Rabbit antibody targeting Streptolysin O. Anti-Streptolysin O Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Streptococcus
Application
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationSecreted; Host cell membrane.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundStreptolysin is a streptococcal hemolytic exotoxin. Types include streptolysin O (SLO), which is oxygen-labile, and streptolysin S (SLS), which is oxygen-stable. An antibody, antistreptolysin O, can be detected in an antistreptolysin O titre. Streptolysin O is hemolytically active only in a reversibly reduced state, unlike streptolysin S, which is stable in the presence of oxygen. Another difference is that SLO is antigenic, while SLS is not antigenic due to its small size. The main function of streptolysin O is to cause hemolysis (the breaking open of red blood cells) — in particular, beta-hemolysis. Increased levels of aso titre in the blood could cause damage to the heart and joints. In most cases, penicillin is used to treat patients with increased levels of aso titre.
Antigen Details
Immunogen
Recombinant Protein: Streptolysin O
Function
Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity).
Chemical Properties
Molecular WeightTheoretical: 64 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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