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Anti-Gli3 Antibody (3M730) is a Rabbit antibody targeting Gli3. Anti-Gli3 Antibody (3M730) can be used in WB,ICC.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $298 | 7-10 days | |
100 μL | $498 | 7-10 days |
Description | Anti-Gli3 Antibody (3M730) is a Rabbit antibody targeting Gli3. Anti-Gli3 Antibody (3M730) can be used in WB,ICC. |
Synonyms | Zinc finger protein GLI3, Zinc finger protein GLI 3, Transcriptional repressor GLI3R, Transcriptional activator GLI3, PPDIV, PPD IV, PHS, PAPB, PAPA1, PAPA 1, PAPA, PAP A, Oncogene GLI3, Glioma associated oncogene family zinc finger 3, GLI3FL, GLI3-83, GLI3-190, GLI3_HUMAN, GLI3 full length protein, GLI3 form of 83 kDa, GLI3 form of 190 kDa, GLI3 C-terminally truncated form, GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome), GLI Kruppel family member GLI3, GLI Kruppel family member GLI 3, GLI family zinc finger 3, GLI 3, Gli 3, GCPS, DNA binding protein, ACLS |
Ig Type | IgG |
Reactivity | Human |
Verified Activity | 1. Western blot analysis of Gli3 on PC-3M cell lysate using anti-Gli3 antibody at 1/1,000 dilution. |
Application | |
Recommended Dose | WB: 1:500-2000; ICC: 1:50-100 |
Antibody Type | Monoclonal |
Host Species | Rabbit |
Construction | Recombinant Antibody |
Purification | ProA affinity purified |
Appearance | Liquid |
Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
Research Background | Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Kr??ppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. GLI-3 (GLI family zinc finger 3), also known as GLI3FL (GLI3 full length protein), PHS, ACLS, GCPS, PAPA, PAPB, PAPA1 or PPDIV, is a 1,580 amino acid nuclear and cytoplasmic protein that acts as both a transcriptional activator and a repressor of the Sonic hedgehog (Shh) pathway. A member of the GLI C2H2-type zinc-finger protein family, GLI-3 is encoded by a gene that maps to human chromosome 7p14.1. Defects in the GLI-3 gene are the cause of a disorder known as Greig cephalo-poly-syndactyly syndrome (GCPS), which affects limb and craniofacial development. |
Conjucates | Unconjugated |
Immunogen | Recombinant Protein: human Gli3 aa 1300-1600 |
Antigen Species | human |
Uniprot ID |
Molecular Weight | Theoretical: 190 kDa. |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
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