Shopping Cart

Your shopping cart is currently empty

Sertraline hydrochloride

Name: Sertraline hydrochloride
Brand: TargetMol
SKU: T0482
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T0482Cas No. 79559-97-0

Alias Sertraline HCl, CP-51974-1 HCl

Sertraline hydrochloride (Sertraline HCl) is a selective serotonin uptake inhibitor that is used in the treatment of depression.

Sertraline hydrochloride

🥰Excellent

Purity: 99.89%

Catalog No. T0482Alias Sertraline HCl, CP-51974-1 HClCas No. 79559-97-0

Sertraline hydrochloride (Sertraline HCl) is a selective serotonin uptake inhibitor that is used in the treatment of depression.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$47	In Stock	In Stock
10 mg	$57	In Stock	In Stock
25 mg	$105	In Stock	In Stock
50 mg	$189	In Stock	In Stock
100 mg	$247	In Stock	In Stock
200 mg	$321	In Stock	In Stock
500 mg	$542	In Stock	-
1 mL x 10 mM (in DMSO)	$52	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.89%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Sertraline hydrochloride (Sertraline HCl) is a selective serotonin uptake inhibitor that is used in the treatment of depression.
Targets&IC50	5-HT:13 nM(Ki)
In vitro	Sertraline HCl significantly enhances locomotor activity in mice during the antidepressant Porsolt forced swim test. Intraperitoneal injection of 32 μMol/kg Sertraline HCl inhibits more than 50% of 5-hydroxytryptamine uptake by rat striatal synaptosomes. Sertraline HCl reverses 5-hydroxytryptamine depletion caused by PCA, proving to be six times more effective than chlorpromazine and sixty times more effective than amitriptyline. Acute repetitive administration of Sertraline reduces the serotonin content in whole blood. Chronic administration of Sertraline HCl in rats decreases the binding of [3H] dihydroalprenolol to cortical membranes and the cyclic AMP response to norepinephrine in the limbic forebrain adenylate cyclase.
In vivo	Sertraline is more effective than fluvoxamine, zimelidine, norzimelidine, fluoxetine, or clomipramine in preferentially inhibiting the uptake of 5-HT (serotonin), with comparatively weaker inhibition of NE (norepinephrine) absorption. However, sertraline exhibits lower selectivity than these agents in blocking the uptake of 5-HT relative to DA (dopamine).
Synonyms	Sertraline HCl, CP-51974-1 HCl

Chemical Properties

Molecular Weight	342.691
Formula	C₁₇H₁₈Cl₃N
Cas No.	79559-97-0
Smiles	Cl.CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc12
Relative Density.	1.37 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 61 mg/mL (178 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.84 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9181 mL	14.5904 mL	29.1808 mL	145.9040 mL
5 mM	0.5836 mL	2.9181 mL	5.8362 mL	29.1808 mL
10 mM	0.2918 mL	1.4590 mL	2.9181 mL	14.5904 mL
20 mM	0.1459 mL	0.7295 mL	1.4590 mL	7.2952 mL
50 mM	0.0584 mL	0.2918 mL	0.5836 mL	2.9181 mL
100 mM	0.0292 mL	0.1459 mL	0.2918 mL	1.4590 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc