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Artefenomel
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Catalog No. T10377Cas No. 1029939-86-3
Alias OZ439, OZ 439
Artefenomel (OZ439) is an orally active anti-malarial ozone analog with antiviral activity for the study of SARS-CoV-2 infections and malaria infections.
Artefenomel
Copy Product Info😃Good
Catalog No. T10377Alias OZ439, OZ 439Cas No. 1029939-86-3
Artefenomel (OZ439) is an orally active anti-malarial ozone analog with antiviral activity for the study of SARS-CoV-2 infections and malaria infections.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $199 | - | In Stock | |
| 2 mg | Preferential | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Appearance:Solid
Color:White
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Storage & Solubility Information
| Description | Artefenomel (OZ439) is an orally active anti-malarial ozone analog with antiviral activity for the study of SARS-CoV-2 infections and malaria infections. |
| Targets&IC50 | SARS-CoV-2:2.9 μM |
| In vitro | Artefenomel (10 μg/mL, 2 hours of action) is capable of alkylating Plasmodium falciparum proteins. [1] In Vero cells, Artefenomel (0.3-300 μM) dose-dependently reduced ACE2 expression and did not exhibit any cytotoxicity even at concentrations up to 300 μM. [2] In a dose-dependent manner, Artefenomel (33-100 μM) inhibited SARS-CoV-2 and completely blocked virus-induced cytopathic effects (CPE) with an IC50 of 2.9 μM. [2] |
| In vivo | Artefenomel (0-10 μg/mL) affects erythrocytes, leading to anemia, which causes histological alterations (e.g., cell death) and significant sarcomeric abnormalities in embryos of pregnant Crl:CD(SD)BR rats. [3] |
| Synonyms | OZ439, OZ 439 |
| Molecular Weight | 469.61 |
| Formula | C28H39NO5 |
| Cas No. | 1029939-86-3 |
| Smiles | O(CCN1CCOCC1)C2=CC=C([C@@H]3CC[C@@]4(OC5([C@]6(CC7C[C@@]5(CC(C6)C7)[H])[H])OO4)CC3)C=C2 |
| Relative Density. | 1.24 g/cm3 (Predicted) |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | DMSO: 2 mg/mL (4.26 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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