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Artefenomel
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Catalog No. T10377Cas No. 1029939-86-3
Alias OZ439, OZ 439
Artefenomel (OZ439) is an orally active anti-malarial ozone analog with antiviral activity for the study of SARS-CoV-2 infections and malaria infections.
Artefenomel
😃Good
Catalog No. T10377Alias OZ439, OZ 439Cas No. 1029939-86-3
Artefenomel (OZ439) is an orally active anti-malarial ozone analog with antiviral activity for the study of SARS-CoV-2 infections and malaria infections.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $199 | - | In Stock | |
| 2 mg | Preferential | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | Artefenomel (OZ439) is an orally active anti-malarial ozone analog with antiviral activity for the study of SARS-CoV-2 infections and malaria infections. |
| Targets&IC50 | SARS-CoV-2:2.9 μM |
| In vitro | Artefenomel (10 μg/mL, 2 hours of action) is capable of alkylating Plasmodium falciparum proteins. [1] In Vero cells, Artefenomel (0.3-300 μM) dose-dependently reduced ACE2 expression and did not exhibit any cytotoxicity even at concentrations up to 300 μM. [2] In a dose-dependent manner, Artefenomel (33-100 μM) inhibited SARS-CoV-2 and completely blocked virus-induced cytopathic effects (CPE) with an IC50 of 2.9 μM. [2] |
| In vivo | Artefenomel (0-10 μg/mL) affects erythrocytes, leading to anemia, which causes histological alterations (e.g., cell death) and significant sarcomeric abnormalities in embryos of pregnant Crl:CD(SD)BR rats. [3] |
| Synonyms | OZ439, OZ 439 |
| Molecular Weight | 469.61 |
| Formula | C28H39NO5 |
| Cas No. | 1029939-86-3 |
| Smiles | O(CCN1CCOCC1)C2=CC=C([C@@H]3CC[C@@]4(OC5([C@]6(CC7C[C@@]5(CC(C6)C7)[H])[H])OO4)CC3)C=C2 |
| Relative Density. | 1.24 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | DMSO: 2 mg/mL (4.26 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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