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Cyclocreatine

Name: Cyclocreatine
Brand: TargetMol
SKU: T40445
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40445Cas No. 35404-50-3

Cyclocreatine, a creatine analogue and substrate for creatine kinase, inhibits creatine metabolism and prostate cancer cell proliferation, improving cognitive, autistic and epileptic phenotypes in mouse models of creatine transporter deficiency (CTD).

Cyclocreatine

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Purity: 99.864%

Catalog No. T40445Cas No. 35404-50-3

Pack Size	Price	Availability
50 mg	$30	In Stock
100 mg	$40	In Stock
500 mg	$92	In Stock
1 g	$133	In Stock

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Purity:99.864%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Cyclocreatine, a creatine analogue and substrate for creatine kinase, inhibits creatine metabolism and prostate cancer cell proliferation, improving cognitive, autistic and epileptic phenotypes in mouse models of creatine transporter deficiency (CTD).
In vitro	Methods: PC3 CL1 cells were treated with Cyclocreatine (0-50 mM, 24 hours), and the effects of Cyclocreatine on creatine uptake and metabolism were investigated using 13C1-creatine tracing technology. Results: Isotope tracing demonstrated that Cyclocreatine dose-dependently inhibited the uptake of 13C-creatine and the production of its metabolites, 13C-creatinine and 13C-phosphocreatine.
In vivo	Methods: Dissolve 1% Cyclocreatine in drinking water and provide it to Pten Spry2pc-/- mice for free consumption over a period of 1 month to observe the effect of Cyclocreatine on prostate tumor growth in these mice. Results: After Cyclocreatine treatment, the proliferation of prostate tumors in mice was significantly reduced, and the proportion of Ki67-positive cells markedly decreased.

Chemical Properties

Molecular Weight	143.14
Formula	C₅H₉N₃O₂
Cas No.	35404-50-3
Smiles	OC(=O)CN1CCNC1=N
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: < 0.7 mg/mL (insoluble)

H2O: 4 mg/mL (27.94 mM), Sonication is recommended.

1M HCl: 80 mg/mL (558.89 mM), when pH is adjusted to 2 with HCl. Sonication is recommended.

In Vivo Formulation

PBS: 10 mg/mL (69.86 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/1M HCl

	1mg	5mg	10mg	50mg
1 mM	6.9862 mL	34.9308 mL	69.8617 mL	349.3084 mL
5 mM	1.3972 mL	6.9862 mL	13.9723 mL	69.8617 mL
10 mM	0.6986 mL	3.4931 mL	6.9862 mL	34.9308 mL
20 mM	0.3493 mL	1.7465 mL	3.4931 mL	17.4654 mL

1M HCl

	1mg	5mg	10mg	50mg
50 mM	0.1397 mL	0.6986 mL	1.3972 mL	6.9862 mL
100 mM	0.0699 mL	0.3493 mL	0.6986 mL	3.4931 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc