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Ragaglitazar

Name: Ragaglitazar
Brand: TargetMol
SKU: T28501
Price: 639 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T28501Cas No. 222834-30-2

Alias NNC61-0029, NNC-61-0029, NNC 61-0029, NN-622, NN 622, (-)-DRF-2725

Ragaglitazar(NNC-61-0029) is a potent dual activator of PPARγ and PPARα, which shows improved insulin sensitization and lipid-lowering potential in animal models and can be used to study type 2 diabetes.

Ragaglitazar

🥰Excellent

Purity: 98.56%

Catalog No. T28501Alias NNC61-0029, NNC-61-0029, NNC 61-0029, NN-622, NN 622, (-)-DRF-2725Cas No. 222834-30-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$639	In Stock	In Stock
5 mg	$1,370	In Stock	In Stock
25 mg	$2,230	In Stock	In Stock
50 mg	$2,780	In Stock	In Stock
100 mg	$3,700	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.56%

ee:96.428%

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COA CSFC HNMR LCMS ORP

Product Introduction

Bioactivity

Description	Ragaglitazar(NNC-61-0029) is a potent dual activator of PPARγ and PPARα, which shows improved insulin sensitization and lipid-lowering potential in animal models and can be used to study type 2 diabetes.
In vitro	METHODS: A comparative dose-response study of PPARγ and PPARα was performed using Ragaglitazar (NNC-61-0029) (0.1, 1, 10, 100 nM). RESULTS Ragaglitazar (NNC-61-0029) showed significant activation of both isoforms. Ragaglitazar showed weaker potency against PPARγ (EC50=324 nm) and more potent activation of PPARα (EC50=270 nm). [1]
In vivo	METHODS: SD rats fed a high-fat diet were treated with Ragaglitazar (NNC-61-0029) (0.1, 0.3, 1, 10, 30 mg/kg) to observe the improvement of blood lipid levels in rats. RESULTS Rats showed a dose-dependent improvement in plasma lipid levels, and plasma Apo CIII levels were significantly reduced in ragaglitazar (10 mg/kg) (P<0.05). [1]
Synonyms	NNC61-0029, NNC-61-0029, NNC 61-0029, NN-622, NN 622, (-)-DRF-2725

Chemical Properties

Molecular Weight	419.47
Formula	C₂₅H₂₅NO₅
Cas No.	222834-30-2
Smiles	C(COC1=CC=C(C[C@H](OCC)C(O)=O)C=C1)N2C=3C(OC=4C2=CC=CC4)=CC=CC3
Relative Density.	1.241 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (119.2 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (5.96 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3840 mL	11.9198 mL	23.8396 mL	119.1980 mL
5 mM	0.4768 mL	2.3840 mL	4.7679 mL	23.8396 mL
10 mM	0.2384 mL	1.1920 mL	2.3840 mL	11.9198 mL
20 mM	0.1192 mL	0.5960 mL	1.1920 mL	5.9599 mL
50 mM	0.0477 mL	0.2384 mL	0.4768 mL	2.3840 mL
100 mM	0.0238 mL	0.1192 mL	0.2384 mL	1.1920 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc