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AP-III-a4 hydrochloride

Name: AP-III-a4 hydrochloride
Brand: TargetMol
SKU: T6759L
Rating: 4.5 (1 reviews)

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Catalog No. T6759LCas No. 2070014-95-6

Alias ENOblock hydrochloride, AP-III-a4 hydrochloride (1177827-73-4 free base)

AP-III-a4 hydrochloride (ENOblock hydrochloride) is a direct enolase (enolase) inhibitor with non-substrate analogs.AP-III-a4 hydrochloride inhibits metastasis of cancer cells in vivo and affects glucose homeostasis and can be used in bioassays.

AP-III-a4 hydrochloride

😃Good

Catalog No. T6759LAlias ENOblock hydrochloride, AP-III-a4 hydrochloride (1177827-73-4 free base)Cas No. 2070014-95-6

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$98	Inquiry	Inquiry
5 mg	$188	Inquiry	Inquiry
10 mg	$302	Inquiry	Inquiry
25 mg	$619	Inquiry	Inquiry
50 mg	$873	Inquiry	Inquiry
100 mg	Inquiry	Inquiry	Inquiry
200 mg	Inquiry	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$260	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	AP-III-a4 hydrochloride (ENOblock hydrochloride) is a direct enolase (enolase) inhibitor with non-substrate analogs.AP-III-a4 hydrochloride inhibits metastasis of cancer cells in vivo and affects glucose homeostasis and can be used in bioassays.
Synonyms	ENOblock hydrochloride, AP-III-a4 hydrochloride (1177827-73-4 free base)

Chemical Properties

Molecular Weight	631.18
Formula	C₃₁H₄₄ClFN₈O₃
Cas No.	2070014-95-6
Smiles	O=C(CC1=CC=C(NC2=NC(NCC3CCCCC3)=NC(NCC4=CC=C(C=C4)F)=N2)C=C1)NCCOCCOCCN.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (63.37 mM), Sonication is recommended.

H2O: 8 mg/mL (12.67 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5843 mL	7.9217 mL	15.8433 mL	79.2167 mL
5 mM	0.3169 mL	1.5843 mL	3.1687 mL	15.8433 mL
10 mM	0.1584 mL	0.7922 mL	1.5843 mL	7.9217 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.0792 mL	0.3961 mL	0.7922 mL	3.9608 mL
50 mM	0.0317 mL	0.1584 mL	0.3169 mL	1.5843 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc