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SIRT7 inhibitor 97491

Name: SIRT7 inhibitor 97491
Brand: TargetMol
SKU: T39233
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39233Cas No. 1807758-81-1

SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.

SIRT7 inhibitor 97491

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Purity: 99.79%

Catalog No. T39233Cas No. 1807758-81-1

SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$97	In Stock	In Stock
5 mg	$247	In Stock	In Stock
10 mg	$372	In Stock	In Stock
25 mg	$629	In Stock	In Stock
50 mg	$896	In Stock	In Stock
100 mg	$1,220	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$272	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.79%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.
Targets&IC50	SIRT7:325 nM
In vitro	SIRT7 inhibitor 97491 (1-10 μM) effectively reduces the proliferation of human uterine sarcoma MES-SA cells by over 50% at 5 and 10 μM after 72 hours, without cytotoxic effects on HEK293 human embryonic kidney cells after 24 hours of exposure, indicating selective action[1].
In vivo	The SIRT7 inhibitor 97491 (2 mg/kg; intraperitoneally injected; for 3 weeks, except on weekends) effectively suppresses tumor growth in xenograft mice[1]. Utilizing Balb/c nude mice (18-20 g; 6-8 weeks old) implanted with MES-SA cells[1], the dosage administered was 2 mg/kg via intraperitoneal injection over a three-week period, excluding weekends. The outcome was a significant inhibition of cancer growth in vivo.

Chemical Properties

Molecular Weight	285.73
Formula	C₁₅H₁₂ClN₃O
Cas No.	1807758-81-1
Smiles	Nc1cccc(Nc2ncc(o2)-c2ccc(Cl)cc2)c1
Relative Density.	1.354 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (874.95 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 5 mg/mL (17.5 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4998 mL	17.4990 mL	34.9981 mL	174.9904 mL
5 mM	0.7000 mL	3.4998 mL	6.9996 mL	34.9981 mL
10 mM	0.3500 mL	1.7499 mL	3.4998 mL	17.4990 mL
20 mM	0.1750 mL	0.8750 mL	1.7499 mL	8.7495 mL
50 mM	0.0700 mL	0.3500 mL	0.7000 mL	3.4998 mL
100 mM	0.0350 mL	0.1750 mL	0.3500 mL	1.7499 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc