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Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2

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Catalog No. T78436Cas No. 720710-69-0

Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a quenched, fluorescent MMP peptide substrate designed for real-time quantification of MMP enzymatic activity. As an extended variant of the MMP substrate (FS-1), it demonstrates increased specificity against collagenases (MMP-1, MMP-8, MMP-13) and MT1-MMP, with higher specificity constants (Ex/Em=325 nm/400 nm). [1]

Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2

Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2

😃Good
Catalog No. T78436Cas No. 720710-69-0
Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a quenched, fluorescent MMP peptide substrate designed for real-time quantification of MMP enzymatic activity. As an extended variant of the MMP substrate (FS-1), it demonstrates increased specificity against collagenases (MMP-1, MMP-8, MMP-13) and MT1-MMP, with higher specificity constants (Ex/Em=325 nm/400 nm). [1]
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Product Introduction

Bioactivity
Description
Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a quenched, fluorescent MMP peptide substrate designed for real-time quantification of MMP enzymatic activity. As an extended variant of the MMP substrate (FS-1), it demonstrates increased specificity against collagenases (MMP-1, MMP-8, MMP-13) and MT1-MMP, with higher specificity constants (Ex/Em=325 nm/400 nm). [1]
Targets&IC50
MMP14:7.9 μM (Km), MMP13:5.2 μM (Km), MMP1:27.5 μM (Km)
In vitro
The compound Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH26 exhibits a catalytic efficiency (kcat/Km) that is 2-9-fold higher in comparison to FS-1 for specific matrix metalloproteinases (MMP-1, MMP-8, MMP-13) and membrane-type 1-MMP (MMP-14), or a 3-fold increase according to reference [1].
Chemical Properties
Molecular Weight1221.32
FormulaC55H80N16O16
Cas No.720710-69-0
SmilesC(C(N[C@H](C(=O)N1[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CNC2=C(N(=O)=O)C=C(N(=O)=O)C=C2)C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(N)=O)=O)C)=O)=O)CC(C)C)=O)=O)CC(C)C)=O)CCC1)CCCCN)=O)C=3C=4C(=CC(OC)=CC4)OC(=O)C3
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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