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Anti-CD16a Antibody-PE (5Q617)
🥰Excellent
Catalog No. TMAY-00743P
Anti-CD16a Antibody-PE (5Q617) is a PE-conjugated Mouse antibody targeting CD16a. Anti-CD16a Antibody-PE (5Q617) can be used in FCM.
Anti-CD16a Antibody-PE (5Q617)
Anti-CD16a Antibody-PE (5Q617)
🥰Excellent
Catalog No. TMAY-00743P
Anti-CD16a Antibody-PE (5Q617) is a PE-conjugated Mouse antibody targeting CD16a. Anti-CD16a Antibody-PE (5Q617) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CD16a Antibody-PE (5Q617) is a PE-conjugated Mouse antibody targeting CD16a. Anti-CD16a Antibody-PE (5Q617) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 5Q617 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human CD16 expression on human whole blood lymphocyte. Cells were stained with PE-conjugated anti-Human CD16. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes. |
| Application | FCM |
| Recommended Dose | 5 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD16a (rh CD16a; TMPY-02816; P08637-1; Met1-Gln208,176F) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also known as CD16a, encodes a transmembrane protein expressed on activated monocytes/macrophages, natural killer (NK) cells, and a subset of T cells. CD16a / FCGR3A is a receptor expressed on NK cells that facilitates antibody dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of various antibodies. CD16a / FCGR3A also has a broader function. CD16a / FCGR3A is directly involved in the lysis of some virus-infected cells and tumor cells by NK cells, independent of antibody binding. Cross-linking of CD16a / FCGR3A on NK cells resulted in increased intracellular Ca2+ levels and a cascade of biochemical events similar to those activated by the T cell receptor. CD16a / FCGR3A on human NK cells is a lysis receptor that mediates the direct killing of some virus infected and tumor cells, independent of antibody ligation. |
| Conjucates | PE |
| Others Formats | Unconjugated/APC/PerCP/FITC |
| Antibody Types Available | 5 |
| Immunogen | Recombinant Human CD16a Protein (TMPY-02816) |
| Antigen Species | Human |
| Biology Area | Fc Receptors, Cancer Drug Targets, ITIM/ITAM Immunoreceptors and Related Molecules |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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